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Publication Date2021-11
14.자연에서 발견한 치료제 후보물질
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3-Carene, a Phytoncide from Pine Tree Has a Sleep-enhancing Effect by Targeting the GABA(A)-benzodiazepine Receptors
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A Deafness Associated Protein TMEM43 Interacts with KCNK3 (TASK-1) Two-pore Domain K+ (K2P) Channel in the Cochlea
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A nonsense TMEM43 variant leads to disruption of connexin-linked function and autosomal dominant auditory neuropathy spectrum disorder
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Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinson's Disease
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Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference
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Activation of mGluR1 negatively modulates glutamate-induced phase shifts of the circadian pacemaker in the mouse suprachiasmatic nucleus
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Active role of glia-like supporting cells in the organ of Corti: Membrane proteins and their roles in hearing
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Adenovirus-induced Reactive Astrogliosis Exacerbates the Pathology of Parkinson's Disease
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Antiallodynic effects of KDS2010, a novel MAO-B inhibitor, via ROS-GABA inhibitory transmission in a paclitaxel-induced tactile hypersensitivity model
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Astersaponin I from Aster koraiensis is a natural viral fusion blocker that inhibits the infection of SARS-CoV-2 variants and syncytium formation
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Astrocyte Specificity and Coverage of hGFAP-CreERT2 [Tg(GFAP-Cre/ERT2)13Kdmc] Mouse Line in Various Brain Regions
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Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus
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Astrocytes render memory flexible by releasing D-serine and regulating NMDAR tone in the hippocampus
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Astrocytic PAR1 and mGluR2/3 control synaptic glutamate time course at hippocampal CA1 synapses
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Astrocytic scar restricting glioblastoma via glutamate–MAO-B activity in glioblastoma-microglia assembloid
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Astrocytic urea cycle detoxifies A beta-derived ammonia while impairing memory in Alzheimer's disease
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Bestrophin1-mediated tonic GABA release from reactive astrocytes prevents the development of seizure-prone network in kainate-injected hippocampi
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C-11-Acetate PET/CT Detects Reactive Astrogliosis Helping Glioma Classification
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CRISPR-Cas9 Gene Editing Protects from the A53T-SNCA Overexpression-Induced Pathology of Parkinson's Disease in Vivo
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Cyclophilin A is an endogenous ligand for the triggering receptor expressed on myeloid cells-2 (TREM2)
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DDC-Promoter-Driven Chemogenetic Activation of SNpc Dopaminergic Neurons Alleviates Parkinsonian Motor Symptoms
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Development of a Laboratory-safe and Low-cost Detection Protocol for SARS-CoV-2 of the Coronavirus Disease 2019 (COVID-19)
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Publication Date2021-06
Differential Proximity of Perisynaptic Astrocytic Best1 at the Excitatory and Inhibitory Tripartite Synapses in APP/PS1 and MAOB-KO Mice Revealed by Lattice Structured Illumination Microscopy
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DMSO-tolerant ornithine decarboxylase (ODC) tandem assay optimised for high-throughput screening
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Journal of Enzyme Inhibition and Medicinal Chemistry, v.38, no.1, pp.309 - 318
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Publication Date2022-11
Dopamine-induced astrocytic Ca2+ signaling in mPFC is mediated by MAO-B in young mice, but by dopamine receptors in adult mice
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Dynamic Changes in the Bridging Collaterals of the Basal Ganglia Circuitry Control Stress-Related Behaviors in Mice
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Excessive Astrocytic GABA Causes Cortical Hypometabolism and Impedes Functional Recovery after Subcortical Stroke
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Excitation-inhibition imbalance leads to alteration of neuronal coherence and neurovascular coupling under acute stress
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Publication Date2021-09
Fine-tuning of dual-SMAD inhibition to differentiate human pluripotent stem cells into neural crest stem cells
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GABA tone regulation and its cognitive functions in the brain
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Nature Reviews Neuroscience, v.24, no.9, pp.523 - 539
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Generation of Astrocyte-Specific MAOB Conditional Knockout Mouse with Minimal Tonic GABA Inhibition
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Publication Date2022-10
Glutamate Permeability of Chicken Best1
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Experimental Neurobiology, v.31, no.5, pp.277 - 288
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High-yield synthesis and purification of recombinant human GABA transaminase for high-throughput screening assays
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Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA
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Inhibiting peripheral and central MAO-B ameliorates joint inflammation and cognitive impairment in rheumatoid arthritis
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EXPERIMENTAL AND MOLECULAR MEDICINE, v.54, no.8, pp.1188 - 1200
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Inhibition of monoamine oxidase B prevents reactive astrogliosis and scar formation in stab wound injury model
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Inhibitors of synaptic vesicle exocytosis reduce surface expression of postsynaptic glutamate receptors
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Publication Date2021-10
KDS2010, a Newly Developed Reversible MAO-B Inhibitor, as an Effective Therapeutic Candidate for Parkinson’s Disease
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KDS2010, a reversible MAO-B inhibitor, extends the lifetime of neural probes by preventing glial scar formation
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Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice
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Lancemaside A from Codonopsis lanceolata: Studies on Antiviral Activity and Mechanism of Action against SARS-CoV-2 and Its Variants of Concern
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Long-lasting forms of plasticity through patterned ultrasound-induced brainwave entrainment
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Long-term inhibition of ODC1 in APP/PS1 mice rescues amyloid pathology and switches astrocytes from a reactive to active state
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Longitudinal intravital imaging of cerebral microinfarction reveals a dynamic astrocyte reaction leading to glial scar formation
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MAO-B Inhibitor, KDS2010, Alleviates Spinal Nerve Ligation-induced Neuropathic Pain in Rats Through Competitively Blocking the BDNF/TrkB/NR2B Signaling
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Mapping Astrocytic and Neuronal μ-opioid Receptor Expression in Various Brain Regions Using MOR-mCherry Reporter Mouse
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Negative Influence of the Hunger State on Rule-observance Behavior in Mice
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Neurotoxic Microglial Activation via IFNγ-Induced Nrf2 Reduction Exacerbating Alzheimer's Disease
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Neurovascular coupling under chronic stress is modified by altered GABAergic interneuron activity
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Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer’s disease
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Optimization of primer sets and detection protocols for SARS-CoV-2 of coronavirus disease 2019 (COVID-19) using PCR and real-time PCR
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Opto-vTrap, an optogenetic trap for reversible inhibition of vesicular release, synaptic transmission, and behavior
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Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient
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Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion
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PyrPeg, a Blood-Brain-Barrier-Penetrating Two-Photon Imaging Probe, Selectively Detects Neuritic Plaques, Not Tau Aggregates
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Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice
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Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis
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Publication Date2021-11-27
Retina-attached slice recording reveals light-triggered tonic GABA signaling in suprachiasmatic nucleus
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Molecular Brain, v.14, no.1
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Revisiting the Role of Astrocytic MAOB in Parkinson's Disease
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.23, no.8