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PyrPeg, a Blood-Brain-Barrier-Penetrating Two-Photon Imaging Probe, Selectively Detects Neuritic Plaques, Not Tau Aggregates

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Title
PyrPeg, a Blood-Brain-Barrier-Penetrating Two-Photon Imaging Probe, Selectively Detects Neuritic Plaques, Not Tau Aggregates
Author(s)
Choi J.-W.; Yeon Ha Ju; Choi Y.; Hyeon S.J.; Gadhe C.G.; Park J.-H.; Kim M.S.; Baek S.; Kim Y.; Park K.D.; Pae A.N.; Ryu H.; Changjoon. Justin Lee; Cho B.R.
Publication Date
2020-06
Journal
ACS CHEMICAL NEUROSCIENCE, v.11, no.12, pp.1801 - 1810
Publisher
AMER CHEMICAL SOC
Abstract
© 2020 American Chemical Society. Amyloid-β (Aβ) tracers have made a significant contribution to the treatment of Alzheimer's disease (AD) by allowing a definitive diagnosis in living patients. Unfortunately, they also detect tau and other protein aggregates that compromise test accuracy. In AD research, there has been a growing need for in vivo Aβ imaging by two-photon microscopy, which enables deep-brain-fluorescence imaging. There is no suitable neuritic Aβ probe for two-photon microscopy. Here we report PyrPeg, a novel two-photon fluorescent probe that can selectively target insoluble Aβ rather than tau and α-synuclein aggregates in the AD model brain and postmortem brain. When injected intravenously, PyrPeg detects the neuritic plaques in the brain and olfactory bulb of the AD model. PyrPeg may serve as a useful blood-brain-barrier-penetrating diagnostic tool for optical and functional monitoring of insoluble forms of Aβ aggregates in the living AD brain
URI
https://pr.ibs.re.kr/handle/8788114/7826
DOI
10.1021/acschemneuro.0c00211
ISSN
1948-7193
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
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