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인지 및 사회성 연구단
인지 및 사회성 연구단
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Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference

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Title
Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference
Author(s)
Min-Ho Nam; Kyung-Seok Han; Jaekwang Lee; Woojin Won; Wuhyun Koh; Jin Young Bae; Junsung Woo; Jayoung Kim; Elliot Kwong; Tae-Yong Choi; Heejung Chun; Seung Eun Lee; Sang-Bum Kim; Ki Duk Park; Se-Young Choi; Yong Chul Bae; C. Justin Lee
Publication Date
2019-07
Journal
CELL REPORTS, v.28, no.5, pp.1154 - 1166.e5
Publisher
CELL PRESS
Abstract
© 2019 The AuthorsThe underlying mechanisms of how positive emotional valence (e.g., pleasure) causes preference of an associated context is poorly understood. Here, we show that activation of astrocytic μ-opioid receptor (MOR) drives conditioned place preference (CPP) by means of specific modulation of astrocytic MOR, an exemplar endogenous Gi protein-coupled receptor (Gi-GPCR), in the CA1 hippocampus. Long-term potentiation (LTP) induced by a subthreshold stimulation with the activation of astrocytic MOR at the Schaffer collateral pathway accounts for the memory acquisition to induce CPP. This astrocytic MOR-mediated LTP induction is dependent on astrocytic glutamate released upon activation of the astrocytic MOR and the consequent activation of the presynaptic mGluR1. The astrocytic MOR-dependent LTP and CPP were recapitulated by a chemogenetic activation of astrocyte-specifically expressed Gi-DREADD hM4Di. Our study reveals that the transduction of inhibitory Gi-signaling into augmented excitatory synaptic transmission through astrocytic glutamate is critical for the acquisition of contextual memory for CPP. Nam et al. demonstrate that activation of hippocampal astrocytic μ-opioid receptor causes glutamate release, which increases the release probability by neuronal presynaptic mGluR1 activation and potentiates synaptic plasticity at the SC-CA1 pathway. This enhanced synaptic transmission and synaptic plasticity account for the acquisition of memory associated with CPP
URI
https://pr.ibs.re.kr/handle/8788114/6905
ISSN
2211-1247
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > Cognitive Glioscience Group(인지 교세포과학 그룹) > Journal Papers (저널논문)
Center for Cognition and Sociality(인지 및 사회성 연구단) > Journal Papers (저널논문)
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