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인지 및 사회성 연구단
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Cyclophilin A is an endogenous ligand for the triggering receptor expressed on myeloid cells-2 (TREM2)

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Title
Cyclophilin A is an endogenous ligand for the triggering receptor expressed on myeloid cells-2 (TREM2)
Author(s)
Ji, Kon-Young; Kim, Su-Man; Yee, Su-Min; Kim, Min-Jae; Ban, Yu-Jin; Kim, Eun-Mi; Lee, Eun-Hee; Choi, Ha-Rim; Yun, Hyosuk; Lee, Chul Won; Yun, Chul-Ho; 이창준; Lee, Hyang Burm; Kang, Hyung-Sik
Publication Date
2021-04
Journal
FASEB Journal, v.35, no.4
Publisher
John Wiley and Sons Inc
Abstract
© 2021 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.Triggering receptor expressed on myeloid cells 2 (TREM2) is a cell surface receptor expressed on macrophages, microglial cells, and pre-osteoclasts, and that participates in diverse cellular function, including inflammation, bone homeostasis, neurological development, and coagulation. In spite of the indispensable role of the TREM2 protein in the maintenance of immune homeostasis and osteoclast differentiation, the exact ligand for TREM2 has not yet been identified. Here, we report a putative TREM2 ligand which is secreted from MC38 cells and identified as a cyclophilin A (CypA). A specific interaction between CypA and TREM2 was shown at both protein and cellular levels. Exogenous CypA specifically interacted and co-localized with TREM2 in RAW264.7 cells, and the physical interactions were shown to regulate TREM2 signaling transduction. The Pro144 residue in the extracellular domain of TREM2 was found to be the specific binding site of CypA. When considered together, this provides evidence that CypA interacts specifically with TREM2 as a potent ligand.
URI
https://pr.ibs.re.kr/handle/8788114/9542
DOI
10.1096/fj.202002325RR
ISSN
0892-6638
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
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