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Neurovascular coupling under chronic stress is modified by altered GABAergic interneuron activity

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Title
Neurovascular coupling under chronic stress is modified by altered GABAergic interneuron activity
Author(s)
Kayoung Han; Jiwoong Min; Myunghee Lee; Bok-Man Kang; Taeyoung Park; Junghyun Hahn; Jaeseung Yei; Juheon Lee; Junsung Woo; C. Justin Lee; Seong-Gi Kim; Minah Suh
Publication Date
2019-12
Journal
JOURNAL OF NEUROSCIENCE, v.39, no.50, pp.10081 - 10095
Publisher
SOC NEUROSCIENCE
Abstract
Neurovascular coupling (NVC), the interaction between neural activity and vascular response, ensures normal brain function by maintaining brain homeostasis. We previously reported altered cerebrovascular responses during functional hyperemia in chronically-stressed animals. However, the underlying neuronal-level changes associated with those hemodynamic changes remained unclear. Here, using in vivo and ex vivo experiments, we investigate the neuronal origins of altered NVC dynamics under chronic stress conditions in adult male mice. Stimulus-evoked hemodynamic and neural responses, especially beta and gamma-band local field potential activity, were significantly lower in chronically-stressed animals, and the NVC relationship, itself, had changed. Further, utilizing acute brain slices, we discovered that the underlying cause of this change was dysfunction of neuronal nitric oxide synthase (nNOS)-mediated vascular responses. Using in situ hybridization (FISH) to check the mRNA expression of several GABAergic subtypes, we confirmed that only nNOS mRNA was significantly decreased in chronically-stressed mice. Ultimately, chronic stress impairs NVC by diminishing nNOS-mediated vasodilation responses to local neural activity. Overall, these findings provide useful information in understanding NVC dynamics in the healthy brain. More importantly, this study reveals that impaired nNOS-mediated NVC function may be a contributory factor in the progression of stress-related diseases. Copyright © 2019 Han et al.
URI
https://pr.ibs.re.kr/handle/8788114/6759
ISSN
0270-6474
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > Cognitive Glioscience Group(인지 교세포과학 그룹) > Journal Papers (저널논문)
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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