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인지 및 사회성 연구단
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Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus

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Title
Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus
Author(s)
Kwak, Hankyul; Wuhyun Koh; Kim, Sangwoo; Song, Kiyeong; Shin, Jeong-Im; Jung Moo Lee; Elliot H. Lee; Bae, Jin Young; Ha, Go Eun; Oh, Ju-Eun; Yongmin Mason Park; Sunpil Kim; Jiesi Feng; Lee, Seung Eun; Choi, Ji Won; Kim, Ki Hun; Kim, Yoo Sung; Woo, Junsung; Lee, Dongsu; Son, Taehwang; Kwon, Soon Woo; Park, Ki Duk; Yoon Bo-Eun; Lee, Jaeick; Yulong Li; Lee, Hyunbeom; Bae, Yong Chul; Changjoon Justin Lee; Cheong, Eunji
Subject
EXTRASYNAPTIC GABA(A) RECEPTORS, ; VENTROBASAL THALAMUS, ; RETICULAR NUCLEUS, ; GENE-EXPRESSION, ; NEURONS, ; ACTIVATION, ; CHANNELS, ; RELEASE, ; DISCRIMINATION, ; PHYSIOLOGY
Publication Date
2020-11-25
Journal
NEURON, v.108, no.4, pp.691 - +
Publisher
CELL PRESS
Abstract
Sensory discrimination is essential for survival. However, how sensory information is finely controlled in the brain is not well defined. Here, we show that astrocytes control tactile acuity via tonic inhibition in the thalamus. Mechanistically, diamine oxidase (DAO) and the subsequent aldehyde dehydrogenase 1a1 (Aldh1a1) convert putrescine into GABA, which is released via Best1 The GABA from astrocytes inhibits synaptically evoked firing at the lemniscal synapses to fine-tune the dynamic range of the stimulation-response relationship, the precision of spike timing, and tactile discrimination. Our findings reveal a novel role of astrocytes in the control of sensory acuity through tonic GABA release.
URI
https://pr.ibs.re.kr/handle/8788114/8921
DOI
10.1016/j.neuron.2020.08.013
ISSN
0896-6273
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
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