BROWSE

Related Scientist

Koh, Wuhyun's photo.

Koh, Wuhyun
인지 및 사회성 연구단
more info

ITEM VIEW & DOWNLOAD

Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus

DC Field Value Language
dc.contributor.authorKwak, Hankyul-
dc.contributor.authorWuhyun Koh-
dc.contributor.authorKim, Sangwoo-
dc.contributor.authorSong, Kiyeong-
dc.contributor.authorShin, Jeong-Im-
dc.contributor.authorJung Moo Lee-
dc.contributor.authorElliot H. Lee-
dc.contributor.authorBae, Jin Young-
dc.contributor.authorHa, Go Eun-
dc.contributor.authorOh, Ju-Eun-
dc.contributor.authorYongmin Mason Park-
dc.contributor.authorSunpil Kim-
dc.contributor.authorJiesi Feng-
dc.contributor.authorLee, Seung Eun-
dc.contributor.authorChoi, Ji Won-
dc.contributor.authorKim, Ki Hun-
dc.contributor.authorKim, Yoo Sung-
dc.contributor.authorWoo, Junsung-
dc.contributor.authorLee, Dongsu-
dc.contributor.authorSon, Taehwang-
dc.contributor.authorKwon, Soon Woo-
dc.contributor.authorPark, Ki Duk-
dc.contributor.authorYoon Bo-Eun-
dc.contributor.authorLee, Jaeick-
dc.contributor.authorYulong Li-
dc.contributor.authorLee, Hyunbeom-
dc.contributor.authorBae, Yong Chul-
dc.contributor.authorChangjoon Justin Lee-
dc.contributor.authorCheong, Eunji-
dc.date.accessioned2020-12-24T05:30:19Z-
dc.date.accessioned2020-12-24T05:30:19Z-
dc.date.available2020-12-24T05:30:19Z-
dc.date.available2020-12-24T05:30:19Z-
dc.date.created2020-12-21-
dc.date.issued2020-11-25-
dc.identifier.issn0896-6273-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/8921-
dc.description.abstractSensory discrimination is essential for survival. However, how sensory information is finely controlled in the brain is not well defined. Here, we show that astrocytes control tactile acuity via tonic inhibition in the thalamus. Mechanistically, diamine oxidase (DAO) and the subsequent aldehyde dehydrogenase 1a1 (Aldh1a1) convert putrescine into GABA, which is released via Best1 The GABA from astrocytes inhibits synaptically evoked firing at the lemniscal synapses to fine-tune the dynamic range of the stimulation-response relationship, the precision of spike timing, and tactile discrimination. Our findings reveal a novel role of astrocytes in the control of sensory acuity through tonic GABA release.-
dc.description.uri1-
dc.language영어-
dc.publisherCELL PRESS-
dc.subjectEXTRASYNAPTIC GABA(A) RECEPTORS-
dc.subjectVENTROBASAL THALAMUS-
dc.subjectRETICULAR NUCLEUS-
dc.subjectGENE-EXPRESSION-
dc.subjectNEURONS-
dc.subjectACTIVATION-
dc.subjectCHANNELS-
dc.subjectRELEASE-
dc.subjectDISCRIMINATION-
dc.subjectPHYSIOLOGY-
dc.titleAstrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000598177400015-
dc.identifier.scopusid2-s2.0-85091356334-
dc.identifier.rimsid74126-
dc.contributor.affiliatedAuthorWuhyun Koh-
dc.contributor.affiliatedAuthorJung Moo Lee-
dc.contributor.affiliatedAuthorYongmin Mason Park-
dc.contributor.affiliatedAuthorSunpil Kim-
dc.contributor.affiliatedAuthorChangjoon Justin Lee-
dc.identifier.doi10.1016/j.neuron.2020.08.013-
dc.identifier.bibliographicCitationNEURON, v.108, no.4, pp.691 - +-
dc.citation.titleNEURON-
dc.citation.volume108-
dc.citation.number4-
dc.citation.startPage691-
dc.citation.endPage+-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaNeurosciences & Neurology-
dc.relation.journalWebOfScienceCategoryNeurosciences-
dc.subject.keywordPlusEXTRASYNAPTIC GABA(A) RECEPTORS-
dc.subject.keywordPlusVENTROBASAL THALAMUS-
dc.subject.keywordPlusRETICULAR NUCLEUS-
dc.subject.keywordPlusGENE-EXPRESSION-
dc.subject.keywordPlusNEURONS-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusCHANNELS-
dc.subject.keywordPlusRELEASE-
dc.subject.keywordPlusDISCRIMINATION-
dc.subject.keywordPlusPHYSIOLOGY-
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse