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Revisiting the Role of Astrocytic MAOB in Parkinson's Disease

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Title
Revisiting the Role of Astrocytic MAOB in Parkinson's Disease
Author(s)
Nam, Min-Ho; Moonsun Sa; Yeon Ha Ju; Mingu Gordon Park; C. Justin Lee
Publication Date
2022-04
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.23, no.8
Publisher
MDPI
Abstract
Monoamine oxidase-B (MAOB) has been believed to mediate the degradation of monoamine neurotransmitters such as dopamine. However, this traditional belief has been challenged by demonstrating that it is not MAOB but MAOA which mediates dopamine degradation. Instead, MAOB mediates the aberrant synthesis of GABA and hydrogen peroxide (H2O2) in reactive astrocytes of Parkinson's disease (PD). Astrocytic GABA tonically suppresses the dopaminergic neuronal activity, whereas H2O2 aggravates astrocytic reactivity and dopaminergic neuronal death. Recently discovered reversible MAOB inhibitors reduce reactive astrogliosis and restore dopaminergic neuronal activity to alleviate PD symptoms in rodents. In this perspective, we redefine the role of MAOB for the aberrant suppression and deterioration of dopaminergic neurons through excessive GABA and H2O2 synthesis of reactive astrocytes in PD.
URI
https://pr.ibs.re.kr/handle/8788114/11740
DOI
10.3390/ijms23084453
ISSN
1661-6596
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
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