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Excitation-inhibition imbalance leads to alteration of neuronal coherence and neurovascular coupling under acute stress

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Title
Excitation-inhibition imbalance leads to alteration of neuronal coherence and neurovascular coupling under acute stress
Author(s)
Kayoung Han; Myunghee Lee; Hyun-Kyoung Lim; Minwoo Wendy Jang; Jea Kwon; C. Justin Lee; Seong-Gi Kim; Minah Suh
Subject
Acute stress, ; E/I balance, ; Neuronal coherence, ; Neurovascular coupling, ; Two-photon imaging
Publication Date
2020-11
Journal
JOURNAL OF NEUROSCIENCE, v.40, no.47, pp.9148 - 9162
Publisher
SOC NEUROSCIENCE
Abstract
© 2020 Han et al. A single stressful event can cause morphologic and functional changes in neurons and even malfunction of vascular systems, which can lead to acute stress disorder or post-traumatic stress disorder. However, there is a lack of evidence regarding how acute stress impacts neuronal activity, the concurrent vascular response, and the relationship between these two factors, which is defined as neurovascular coupling. Here, using in vivo two-photon imaging, we found that NMDA-evoked calcium transients of excitatory neurons were impaired and that vasodilation of penetrating arterioles was concomitantly disrupted in acutely stressed male mice. Furthermore, acute stress altered the relationship between excitatory neuronal calcium coherence and vascular responses. By measuring NMDA-evoked excitatory and inhibitory neuronal calcium activity in acute brain slices, we confirmed that neuronal coherence both between excitatory neurons and between excitatory and inhibitory neurons was reduced by acute stress but restored by blockade of glucocorticoid receptor signaling. Furthermore, the ratio of sEPSCs to sIPSCs was altered by acute stress, suggesting that the excitation-inhibition balance was disrupted by acute stress. In summary, in vivo, ex vivo, and whole-cell recording studies demonstrate that acute stress modifies excitatory-inhibitory neuronal coherence, disrupts the excitation-inhibition balance, and causes consequent neurovascular coupling changes, providing critical insights into the neural mechanism of stress-induced disorders
URI
https://pr.ibs.re.kr/handle/8788114/7543
DOI
10.1523/JNEUROSCI.1553-20.2020
ISSN
0270-6474
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
Center for Cognition and Sociality(인지 및 사회성 연구단) > Cognitive Glioscience Group(인지 교세포과학 그룹) > 1. Journal Papers (저널논문)
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
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