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Non-invasive optical control of endogenous Ca2+ channels in awake mice

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Title
Non-invasive optical control of endogenous Ca2+ channels in awake mice
Author(s)
Kim S.; Taeyoon Kyung; Chung J.-H.; Nury Kim; Sehoon Keum; Lee J.; Park H.; Ho Min Kim; Sangkyu Lee; Hee-Sup Shin; Won Do Heo
Publication Date
2020-01
Journal
NATURE COMMUNICATIONS, v.11, no.1, pp.210 -
Publisher
NATURE PUBLISHING GROUP
Abstract
© 2020, The Author(s).Optogenetic approaches for controlling Ca2+ channels provide powerful means for modulating diverse Ca2+-specific biological events in space and time. However, blue light-responsive photoreceptors are, in principle, considered inadequate for deep tissue stimulation unless accompanied by optic fiber insertion. Here, we present an ultra-light-sensitive optogenetic Ca2+ modulator, named monSTIM1 encompassing engineered cryptochrome2 for manipulating Ca2+ signaling in the brain of awake mice through non-invasive light delivery. Activation of monSTIM1 in either excitatory neurons or astrocytes of mice brain is able to induce Ca2+-dependent gene expression without any mechanical damage in the brain. Furthermore, we demonstrate that non-invasive Ca2+ modulation in neurons can be sufficiently and effectively translated into changes in behavioral phenotypes of awake mice
URI
https://pr.ibs.re.kr/handle/8788114/7031
ISSN
2041-1723
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > Social Neuroscience Group(사회성 뇌과학 그룹) > Journal Papers (저널논문)
Center for Cognition and Sociality(인지 및 사회성 연구단) > Journal Papers (저널논문)
Pioneer Research Center for Biomolecular and Cellular Structure(바이오분자 및 세포구조 연구단) > Protein Communication Group(단백질 커뮤니케이션 그룹) > Journal Papers (저널논문)
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