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단백질커뮤니케이션그룹
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Non-invasive optical control of endogenous Ca2+ channels in awake mice

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dc.contributor.authorKim S.-
dc.contributor.authorTaeyoon Kyung-
dc.contributor.authorChung J.-H.-
dc.contributor.authorNury, Kim-
dc.contributor.authorSehoon Keum-
dc.contributor.authorLee J.-
dc.contributor.authorPark H.-
dc.contributor.authorHo Min Kim-
dc.contributor.authorSangkyu Lee-
dc.contributor.authorHee-Sup Shin-
dc.contributor.authorWon Do Heo-
dc.date.available2020-03-18T08:17:57Z-
dc.date.created2020-02-17-
dc.date.issued2020-01-
dc.identifier.issn2041-1723-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/7031-
dc.description.abstract© 2020, The Author(s).Optogenetic approaches for controlling Ca2+ channels provide powerful means for modulating diverse Ca2+-specific biological events in space and time. However, blue light-responsive photoreceptors are, in principle, considered inadequate for deep tissue stimulation unless accompanied by optic fiber insertion. Here, we present an ultra-light-sensitive optogenetic Ca2+ modulator, named monSTIM1 encompassing engineered cryptochrome2 for manipulating Ca2+ signaling in the brain of awake mice through non-invasive light delivery. Activation of monSTIM1 in either excitatory neurons or astrocytes of mice brain is able to induce Ca2+-dependent gene expression without any mechanical damage in the brain. Furthermore, we demonstrate that non-invasive Ca2+ modulation in neurons can be sufficiently and effectively translated into changes in behavioral phenotypes of awake mice-
dc.language영어-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleNon-invasive optical control of endogenous Ca2+ channels in awake mice-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000510942500001-
dc.identifier.scopusid2-s2.0-85077683711-
dc.identifier.rimsid71207-
dc.contributor.affiliatedAuthorNury, Kim-
dc.contributor.affiliatedAuthorSehoon Keum-
dc.contributor.affiliatedAuthorHo Min Kim-
dc.contributor.affiliatedAuthorSangkyu Lee-
dc.contributor.affiliatedAuthorHee-Sup Shin-
dc.contributor.affiliatedAuthorWon Do Heo-
dc.identifier.doi10.1038/s41467-019-14005-4-
dc.identifier.bibliographicCitationNATURE COMMUNICATIONS, v.11, no.1, pp.210-
dc.relation.isPartOfNATURE COMMUNICATIONS-
dc.citation.titleNATURE COMMUNICATIONS-
dc.citation.volume11-
dc.citation.number1-
dc.citation.startPage210-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.subject.keywordPlusBRAIN-
dc.subject.keywordPlusPROTEIN-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusCORTEX-
dc.subject.keywordPlusDOMAIN-
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
Pioneer Research Center for Biomolecular and Cellular Structure(바이오분자 및 세포구조 연구단) > Protein Communication Group(단백질 커뮤니케이션 그룹) > 1. Journal Papers (저널논문)
Center for Cognition and Sociality(인지 및 사회성 연구단) > Social Neuroscience Group(사회성 뇌과학 그룹) > 1. Journal Papers (저널논문)
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