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Ravi Verma
면역 미생물 공생 연구단
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Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3(+) regulatory T cells

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Title
Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3(+) regulatory T cells
Author(s)
Ravi Verma; Changhon Lee; Eun-Ji Jeun; Jaeu Yi; Kwang Soon Kim; Ambarnil Ghosh; Seohyun Byun; Choong-Gu Lee; Hye-Ji Kang; Gi-Cheon Kim; Chang-Duk Jun; Gwenaël Jan; Chang-Hee Suh; Ju-Yang Jung; Jonathan Sprent; Dipayan Rudra; Cristina De Castro; Antonio Molinaro; Charles D. Surh; Sin-Hyeog Im
Publication Date
2018-10
Journal
SCIENCE IMMUNOLOGY, v.3, no.28, pp.aat6975 -
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Abstract
Dysregulation of intestinal microflora is linked to inflammatory disorders associated with compromised immunosuppressive functions of Foxp3(+) T regulatory (T-r(eg)) cells. Although mucosa-associated commensal microbiota has been implicated in T-reg generation, molecular identities of the "effector" components controlling this process remain largely unknown. Here, we have defined Bifidobacterium bifidum as a potent inducer of Foxp3(+) T-reg cells with diverse T cell receptor specificity to dietary antigens, commensal bacteria, and B. bifidum itself. Cell surface beta-glucan/galactan (CSGG) polysaccharides of B. bifidum were identified as key components responsible for T-reg induction. CSGG efficiently recapitulated the activity of whole bacteria and acted via regulatory dendritic cells through a partially Toll-like receptor 2-mediated mechanism. T-reg cells induced by B. bifidum or purified CSGG display stable and robust suppressive capacity toward experimental colitis. By identifying CSGG as a functional component of T-reg-inducing bacteria, our studies highlight the immunomodulatory potential of CSGG and CSGG-producing microbes © The Authors
URI
https://pr.ibs.re.kr/handle/8788114/5422
ISSN
2470-9468
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
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