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Ravi Verma
면역 미생물 공생 연구단
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Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3(+) regulatory T cells

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dc.contributor.authorRavi Verma-
dc.contributor.authorChanghon Lee-
dc.contributor.authorEun-Ji Jeun-
dc.contributor.authorJaeu Yi-
dc.contributor.authorKwang Soon Kim-
dc.contributor.authorAmbarnil Ghosh-
dc.contributor.authorSeohyun Byun-
dc.contributor.authorChoong-Gu Lee-
dc.contributor.authorHye-Ji Kang-
dc.contributor.authorGi-Cheon Kim-
dc.contributor.authorChang-Duk Jun-
dc.contributor.authorGwenaël Jan-
dc.contributor.authorChang-Hee Suh-
dc.contributor.authorJu-Yang Jung-
dc.contributor.authorJonathan Sprent-
dc.contributor.authorDipayan Rudra-
dc.contributor.authorCristina De Castro-
dc.contributor.authorAntonio Molinaro-
dc.contributor.authorCharles D. Surh-
dc.contributor.authorSin-Hyeog Im-
dc.date.available2019-01-30T02:00:40Z-
dc.date.created2019-01-07-
dc.date.issued2018-10-
dc.identifier.issn2470-9468-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/5422-
dc.description.abstractDysregulation of intestinal microflora is linked to inflammatory disorders associated with compromised immunosuppressive functions of Foxp3(+) T regulatory (T-r(eg)) cells. Although mucosa-associated commensal microbiota has been implicated in T-reg generation, molecular identities of the "effector" components controlling this process remain largely unknown. Here, we have defined Bifidobacterium bifidum as a potent inducer of Foxp3(+) T-reg cells with diverse T cell receptor specificity to dietary antigens, commensal bacteria, and B. bifidum itself. Cell surface beta-glucan/galactan (CSGG) polysaccharides of B. bifidum were identified as key components responsible for T-reg induction. CSGG efficiently recapitulated the activity of whole bacteria and acted via regulatory dendritic cells through a partially Toll-like receptor 2-mediated mechanism. T-reg cells induced by B. bifidum or purified CSGG display stable and robust suppressive capacity toward experimental colitis. By identifying CSGG as a functional component of T-reg-inducing bacteria, our studies highlight the immunomodulatory potential of CSGG and CSGG-producing microbes © The Authors-
dc.languageENG-
dc.publisherAMER ASSOC ADVANCEMENT SCIENCE-
dc.titleCell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3(+) regulatory T cells-
dc.typeArticle-
dc.type.rimsA-
dc.identifier.wosid000449233400004-
dc.identifier.scopusids2.0-850550765079-
dc.contributor.affiliatedAuthorRavi Verma-
dc.contributor.affiliatedAuthorKwang Soon Kim-
dc.contributor.affiliatedAuthorAmbarnil Ghosh-
dc.contributor.affiliatedAuthorChoong-Gu Lee-
dc.contributor.affiliatedAuthorHye-Ji Kang-
dc.contributor.affiliatedAuthorGi-Cheon Kim-
dc.contributor.affiliatedAuthorDipayan Rudra-
dc.contributor.affiliatedAuthorCharles D. Surh-
dc.contributor.affiliatedAuthorSin-Hyeog Im-
dc.identifier.bibliographicCitationSCIENCE IMMUNOLOGY, v.3, no.28, pp.aat6975 --
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
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