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Contagious Aggregation: Transmittable Protein Aggregation in Cellular Communities Initiated by Synthetic Cells

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Title
Contagious Aggregation: Transmittable Protein Aggregation in Cellular Communities Initiated by Synthetic Cells
Author(s)
Hong-Guen Lee; Kim, Jin Hae; Tumpa Gorai; Young Ho Ko; Haw-Young Kwon; Chung, Wooseong; Ilha Hwang; Lim, Sungsu; Kim, Yun Kyung; Shin, Kwanwoo; Young-Tae Chang; Kimoon Kim; Kyeng Min Park
Publication Date
2022-03
Journal
Journal of the American Chemical Society, v.144, no.11, pp.5067 - 5073
Publisher
American Chemical Society
Abstract
© 2021 American Chemical Society. All rights reserved.Aggregation of amyloidogenic proteins causing neurodegenerative diseases is an uncontrollable and contagious process that is often associated with lipid membranes in a highly complex physiological environment. Although several approaches using natural cells and membrane models have been reported, systematic investigations focusing on the association with the membranes are highly challenging, mostly because of the lack of proper molecular tools. Here, we report a new supramolecular approach using a synthetic cell system capable of controlling the initiation of protein aggregation and mimicking various conditions of lipid membranes, thereby enabling systematic investigations of membrane-dependent effects on protein aggregation by visualization. Extending this strategy through concurrent use of synthetic cells and natural cells, we demonstrate the potential of this approach for systematic and in-depth studies on interrogating inter- and intracellularly transmittable protein aggregation. Thus, this new approach offers opportunities for gaining insights into the pathological implications of contagious protein aggregation associated with membranes for neurotoxicity.
URI
https://pr.ibs.re.kr/handle/8788114/11570
DOI
10.1021/jacs.1c13545
ISSN
0002-7863
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
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