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복잡계자기조립연구단
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Contagious Aggregation: Transmittable Protein Aggregation in Cellular Communities Initiated by Synthetic Cells

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dc.contributor.authorHong-Guen Lee-
dc.contributor.authorKim, Jin Hae-
dc.contributor.authorTumpa Gorai-
dc.contributor.authorYoung Ho Ko-
dc.contributor.authorHaw-Young Kwon-
dc.contributor.authorChung, Wooseong-
dc.contributor.authorIlha Hwang-
dc.contributor.authorLim, Sungsu-
dc.contributor.authorKim, Yun Kyung-
dc.contributor.authorShin, Kwanwoo-
dc.contributor.authorYoung-Tae Chang-
dc.contributor.authorKimoon Kim-
dc.contributor.authorKyeng Min Park-
dc.date.accessioned2022-05-25T04:42:37Z-
dc.date.available2022-05-25T04:42:37Z-
dc.date.created2022-03-29-
dc.date.issued2022-03-
dc.identifier.issn0002-7863-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/11570-
dc.description.abstract© 2021 American Chemical Society. All rights reserved.Aggregation of amyloidogenic proteins causing neurodegenerative diseases is an uncontrollable and contagious process that is often associated with lipid membranes in a highly complex physiological environment. Although several approaches using natural cells and membrane models have been reported, systematic investigations focusing on the association with the membranes are highly challenging, mostly because of the lack of proper molecular tools. Here, we report a new supramolecular approach using a synthetic cell system capable of controlling the initiation of protein aggregation and mimicking various conditions of lipid membranes, thereby enabling systematic investigations of membrane-dependent effects on protein aggregation by visualization. Extending this strategy through concurrent use of synthetic cells and natural cells, we demonstrate the potential of this approach for systematic and in-depth studies on interrogating inter- and intracellularly transmittable protein aggregation. Thus, this new approach offers opportunities for gaining insights into the pathological implications of contagious protein aggregation associated with membranes for neurotoxicity.-
dc.language영어-
dc.publisherAmerican Chemical Society-
dc.titleContagious Aggregation: Transmittable Protein Aggregation in Cellular Communities Initiated by Synthetic Cells-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000777169400042-
dc.identifier.scopusid2-s2.0-85126585567-
dc.identifier.rimsid77960-
dc.contributor.affiliatedAuthorHong-Guen Lee-
dc.contributor.affiliatedAuthorTumpa Gorai-
dc.contributor.affiliatedAuthorYoung Ho Ko-
dc.contributor.affiliatedAuthorHaw-Young Kwon-
dc.contributor.affiliatedAuthorIlha Hwang-
dc.contributor.affiliatedAuthorYoung-Tae Chang-
dc.contributor.affiliatedAuthorKimoon Kim-
dc.contributor.affiliatedAuthorKyeng Min Park-
dc.identifier.doi10.1021/jacs.1c13545-
dc.identifier.bibliographicCitationJournal of the American Chemical Society, v.144, no.11, pp.5067 - 5073-
dc.relation.isPartOfJournal of the American Chemical Society-
dc.citation.titleJournal of the American Chemical Society-
dc.citation.volume144-
dc.citation.number11-
dc.citation.startPage5067-
dc.citation.endPage5073-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.subject.keywordPlusCHEMICAL COMMUNICATION-
dc.subject.keywordPlusALPHA-SYNUCLEIN-
dc.subject.keywordPlusPROTOCELL-
dc.subject.keywordPlusBEHAVIOR-
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
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