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Soft implantable drug delivery device integrated wirelessly with wearable devices to treat fatal seizures

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Title
Soft implantable drug delivery device integrated wirelessly with wearable devices to treat fatal seizures
Author(s)
Hyunwoo Joo; Youngsik Lee; Jaemin Kim; Yoo, Jeong-Suk; Seungwon Yoo; Sangyeon Kim; Arya, Ashwini Kumar; Kim, Sangjun; Seung Hong Choi; Lu, Nanshu; Lee, Han Sang; Kim, Sanghoek; Lee, Soon-Tae; Dae-Hyeong Kim
Publication Date
2021-01
Journal
SCIENCE ADVANCES, v.7, no.1
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Abstract
Personalized biomedical devices have enormous potential to solve clinical challenges in urgent medical situations. Despite this potential, a device for in situ treatment of fatal seizures using pharmaceutical methods has not been developed yet. Here, we present a novel treatment system for neurological medical emergencies, such as status epilepticus, a fatal epileptic condition that requires immediate treatment, using a soft implantable drug delivery device (SID). The SID is integrated wirelessly with wearable devices for monitoring electroencephalography signals and triggering subcutaneous drug release through wireless voltage induction. Because of the wireless integration, bulky rigid components such as sensors, batteries, and electronic circuits can be moved from the SID to wearables, and thus, the mechanical softness and miniaturization of the SID are achieved. The efficacy of the prompt treatment could be demonstrated with animal experiments in vivo, in which brain damages were reduced and survival rates were increased.
URI
https://pr.ibs.re.kr/handle/8788114/9939
DOI
10.1126/sciadv.abd4639
ISSN
2375-2548
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
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