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Soft implantable drug delivery device integrated wirelessly with wearable devices to treat fatal seizures

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dc.contributor.authorHyunwoo Joo-
dc.contributor.authorYoungsik Lee-
dc.contributor.authorJaemin Kim-
dc.contributor.authorYoo, Jeong-Suk-
dc.contributor.authorSeungwon Yoo-
dc.contributor.authorSangyeon Kim-
dc.contributor.authorArya, Ashwini Kumar-
dc.contributor.authorKim, Sangjun-
dc.contributor.authorSeung Hong Choi-
dc.contributor.authorLu, Nanshu-
dc.contributor.authorLee, Han Sang-
dc.contributor.authorKim, Sanghoek-
dc.contributor.authorLee, Soon-Tae-
dc.contributor.authorDae-Hyeong Kim-
dc.date.accessioned2021-07-12T06:30:25Z-
dc.date.accessioned2021-07-12T06:30:25Z-
dc.date.available2021-07-12T06:30:25Z-
dc.date.available2021-07-12T06:30:25Z-
dc.date.created2021-02-23-
dc.date.issued2021-01-
dc.identifier.issn2375-2548-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/9939-
dc.description.abstractPersonalized biomedical devices have enormous potential to solve clinical challenges in urgent medical situations. Despite this potential, a device for in situ treatment of fatal seizures using pharmaceutical methods has not been developed yet. Here, we present a novel treatment system for neurological medical emergencies, such as status epilepticus, a fatal epileptic condition that requires immediate treatment, using a soft implantable drug delivery device (SID). The SID is integrated wirelessly with wearable devices for monitoring electroencephalography signals and triggering subcutaneous drug release through wireless voltage induction. Because of the wireless integration, bulky rigid components such as sensors, batteries, and electronic circuits can be moved from the SID to wearables, and thus, the mechanical softness and miniaturization of the SID are achieved. The efficacy of the prompt treatment could be demonstrated with animal experiments in vivo, in which brain damages were reduced and survival rates were increased.-
dc.description.uri1-
dc.language영어-
dc.publisherAMER ASSOC ADVANCEMENT SCIENCE-
dc.titleSoft implantable drug delivery device integrated wirelessly with wearable devices to treat fatal seizures-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000605159200023-
dc.identifier.scopusid2-s2.0-85098688945-
dc.identifier.rimsid74619-
dc.contributor.affiliatedAuthorHyunwoo Joo-
dc.contributor.affiliatedAuthorYoungsik Lee-
dc.contributor.affiliatedAuthorJaemin Kim-
dc.contributor.affiliatedAuthorSeungwon Yoo-
dc.contributor.affiliatedAuthorSangyeon Kim-
dc.contributor.affiliatedAuthorSeung Hong Choi-
dc.contributor.affiliatedAuthorDae-Hyeong Kim-
dc.identifier.doi10.1126/sciadv.abd4639-
dc.identifier.bibliographicCitationSCIENCE ADVANCES, v.7, no.1-
dc.citation.titleSCIENCE ADVANCES-
dc.citation.volume7-
dc.citation.number1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.subject.keywordPlusSTATUS EPILEPTICUS-
dc.subject.keywordPlusPERFORMANCE-
dc.subject.keywordPlusMODELS-
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
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