Surface ligands in synthesis, modification, assembly and biomedical applications of nanoparticles
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Title
- Surface ligands in synthesis, modification, assembly and biomedical applications of nanoparticles
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Author(s)
- Daishun Ling; Michael J. Hackett; Taeg Hwan Hyeon
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Subject
- Ligand, ; Nanoparticle, ; Assembly, ; Surface modification, ; Nanomedicine
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Publication Date
- 2014-08
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Journal
- NANO TODAY, v.9, no.4, pp.457 - 477
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Publisher
- ELSEVIER SCI LTD
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Abstract
- Nanotechnology hasreceivedextraordinaryattentionrecentlyduetoitsburgeon-
ing roleinbiomedicalscience.Thematerialscomposingthenanoparticlesproducefascinating
and diversefunctionalitiesasaresultoftheirexceptionallysmallsize.Infact,evenseemingly
insignificant changesinparticlesizecanhaveprofoundeffectsontheseproperties.Thussize
control, bothduringsynthesisandinparticlesuspensions,isa sine quanon for functionality.
This canbeaccomplishedbymaskingtheparticlesurfacewithamultitudeofdifferentlig-
ands. Notonlycansurfaceligandsconstrainthegrowthofnucleation,theycanalsodirectthe
shape ofcrystallization.Howevernosingleligandcandoeverything.Fortunatelyligandsare
essentially fungibleandcanbeexchangedatvarioustimestoconferthedesiredproperties
to theparticle.Thiscanincludeprotectingtheparticlefromharshaqueousconditions,such
as pHextremes,maximizingopticalpropertiesfordiagnosticsorshieldingtheparticlefrom
potentially hostileconditionsfoundinthebody.Becausethesemoietiesinteractubiquitously
with variousbiologicalmaterials,particularlyproteins,thereneedstobearationalizeddesign
of surfaceligands.Thedesignoftheligandcanhavecrucialeffectsonbiodistributionaswell
as evasionofbiologicaldefenses.Ligandscanevenbedesignedtoprovidenewfunctionality
in responsetovariousenvironmentalstimulitoimprovetheirtherapeuticordiagnosticcapa-
bilities. Consideringtheimportanceofligandsthenonthisemergingfield,thisreviewwill
thoroughly considertheliganddesignforthevariousstepsofnanodevelopment,fromsynthesis
and assemblythroughbiomedicaltranslation.
© 2014ElsevierLtd.Allrightsreserved.
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URI
- https://pr.ibs.re.kr/handle/8788114/938
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DOI
- 10.1016/j.nantod.2014.06.005
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ISSN
- 1748-0132
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Appears in Collections:
- Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
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