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나노입자 연구단
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Surface ligands in synthesis, modification, assembly and biomedical applications of nanoparticles

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Title
Surface ligands in synthesis, modification, assembly and biomedical applications of nanoparticles
Author(s)
Daishun Ling; Michael J. Hackett; Taeg Hwan Hyeon
Publication Date
2014-08
Journal
NANO TODAY, v.9, no.4, pp.457 - 477
Publisher
ELSEVIER SCI LTD
Abstract
Nanotechnology hasreceivedextraordinaryattentionrecentlyduetoitsburgeon- ing roleinbiomedicalscience.Thematerialscomposingthenanoparticlesproducefascinating and diversefunctionalitiesasaresultoftheirexceptionallysmallsize.Infact,evenseemingly insignificant changesinparticlesizecanhaveprofoundeffectsontheseproperties.Thussize control, bothduringsynthesisandinparticlesuspensions,isa sine quanon for functionality. This canbeaccomplishedbymaskingtheparticlesurfacewithamultitudeofdifferentlig- ands. Notonlycansurfaceligandsconstrainthegrowthofnucleation,theycanalsodirectthe shape ofcrystallization.Howevernosingleligandcandoeverything.Fortunatelyligandsare essentially fungibleandcanbeexchangedatvarioustimestoconferthedesiredproperties to theparticle.Thiscanincludeprotectingtheparticlefromharshaqueousconditions,such as pHextremes,maximizingopticalpropertiesfordiagnosticsorshieldingtheparticlefrom potentially hostileconditionsfoundinthebody.Becausethesemoietiesinteractubiquitously with variousbiologicalmaterials,particularlyproteins,thereneedstobearationalizeddesign of surfaceligands.Thedesignoftheligandcanhavecrucialeffectsonbiodistributionaswell as evasionofbiologicaldefenses.Ligandscanevenbedesignedtoprovidenewfunctionality in responsetovariousenvironmentalstimulitoimprovetheirtherapeuticordiagnosticcapa- bilities. Consideringtheimportanceofligandsthenonthisemergingfield,thisreviewwill thoroughly considertheliganddesignforthevariousstepsofnanodevelopment,fromsynthesis and assemblythroughbiomedicaltranslation. © 2014ElsevierLtd.Allrightsreserved.
URI
https://pr.ibs.re.kr/handle/8788114/938
ISSN
1748-0132
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
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