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Surface ligands in synthesis, modification, assembly and biomedical applications of nanoparticles

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dc.contributor.authorDaishun Ling-
dc.contributor.authorMichael J. Hackett-
dc.contributor.authorTaeg Hwan Hyeon-
dc.date.available2015-04-20T05:35:31Z-
dc.date.created2014-11-12-
dc.date.issued2014-08-
dc.identifier.issn1748-0132-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/938-
dc.description.abstractNanotechnology hasreceivedextraordinaryattentionrecentlyduetoitsburgeon- ing roleinbiomedicalscience.Thematerialscomposingthenanoparticlesproducefascinating and diversefunctionalitiesasaresultoftheirexceptionallysmallsize.Infact,evenseemingly insignificant changesinparticlesizecanhaveprofoundeffectsontheseproperties.Thussize control, bothduringsynthesisandinparticlesuspensions,isa sine quanon for functionality. This canbeaccomplishedbymaskingtheparticlesurfacewithamultitudeofdifferentlig- ands. Notonlycansurfaceligandsconstrainthegrowthofnucleation,theycanalsodirectthe shape ofcrystallization.Howevernosingleligandcandoeverything.Fortunatelyligandsare essentially fungibleandcanbeexchangedatvarioustimestoconferthedesiredproperties to theparticle.Thiscanincludeprotectingtheparticlefromharshaqueousconditions,such as pHextremes,maximizingopticalpropertiesfordiagnosticsorshieldingtheparticlefrom potentially hostileconditionsfoundinthebody.Becausethesemoietiesinteractubiquitously with variousbiologicalmaterials,particularlyproteins,thereneedstobearationalizeddesign of surfaceligands.Thedesignoftheligandcanhavecrucialeffectsonbiodistributionaswell as evasionofbiologicaldefenses.Ligandscanevenbedesignedtoprovidenewfunctionality in responsetovariousenvironmentalstimulitoimprovetheirtherapeuticordiagnosticcapa- bilities. Consideringtheimportanceofligandsthenonthisemergingfield,thisreviewwill thoroughly considertheliganddesignforthevariousstepsofnanodevelopment,fromsynthesis and assemblythroughbiomedicaltranslation. © 2014ElsevierLtd.Allrightsreserved.-
dc.description.uri1-
dc.language영어-
dc.publisherELSEVIER SCI LTD-
dc.subjectLigand-
dc.subjectNanoparticle-
dc.subjectAssembly-
dc.subjectSurface modification-
dc.subjectNanomedicine-
dc.titleSurface ligands in synthesis, modification, assembly and biomedical applications of nanoparticles-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000342533000008-
dc.identifier.scopusid2-s2.0-84910014159-
dc.identifier.rimsid16411ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorDaishun Ling-
dc.contributor.affiliatedAuthorMichael J. Hackett-
dc.contributor.affiliatedAuthorTaeg Hwan Hyeon-
dc.identifier.doi10.1016/j.nantod.2014.06.005-
dc.identifier.bibliographicCitationNANO TODAY, v.9, no.4, pp.457 - 477-
dc.citation.titleNANO TODAY-
dc.citation.volume9-
dc.citation.number4-
dc.citation.startPage457-
dc.citation.endPage477-
dc.date.scptcdate2018-10-01-
dc.description.wostc71-
dc.description.scptc76-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusFUNCTIONALIZED GOLD NANOPARTICLES-
dc.subject.keywordPlusIRON-OXIDE NANOPARTICLES-
dc.subject.keywordPlusACCELERATED BLOOD CLEARANCE-
dc.subject.keywordPlusSEMICONDUCTOR QUANTUM DOTS-
dc.subject.keywordPlusAMPHIPHILIC TRIBLOCK COPOLYMERS-
dc.subject.keywordPlusCORE-SHELL NANOPARTICLES-
dc.subject.keywordPlusTARGETED DRUG-DELIVERY-
dc.subject.keywordPlusIMAGING IN-VIVO-
dc.subject.keywordPlusCDSE NANOCRYSTALS-
dc.subject.keywordPlusCONTRAST AGENTS-
dc.subject.keywordAuthorLigand-
dc.subject.keywordAuthorNanoparticle-
dc.subject.keywordAuthorAssembly-
dc.subject.keywordAuthorSurface modification-
dc.subject.keywordAuthorNanomedicine-
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
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