Surface ligands in synthesis, modification, assembly and biomedical applications of nanoparticles
DC Field | Value | Language |
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dc.contributor.author | Daishun Ling | - |
dc.contributor.author | Michael J. Hackett | - |
dc.contributor.author | Taeg Hwan Hyeon | - |
dc.date.available | 2015-04-20T05:35:31Z | - |
dc.date.created | 2014-11-12 | - |
dc.date.issued | 2014-08 | - |
dc.identifier.issn | 1748-0132 | - |
dc.identifier.uri | https://pr.ibs.re.kr/handle/8788114/938 | - |
dc.description.abstract | Nanotechnology hasreceivedextraordinaryattentionrecentlyduetoitsburgeon- ing roleinbiomedicalscience.Thematerialscomposingthenanoparticlesproducefascinating and diversefunctionalitiesasaresultoftheirexceptionallysmallsize.Infact,evenseemingly insignificant changesinparticlesizecanhaveprofoundeffectsontheseproperties.Thussize control, bothduringsynthesisandinparticlesuspensions,isa sine quanon for functionality. This canbeaccomplishedbymaskingtheparticlesurfacewithamultitudeofdifferentlig- ands. Notonlycansurfaceligandsconstrainthegrowthofnucleation,theycanalsodirectthe shape ofcrystallization.Howevernosingleligandcandoeverything.Fortunatelyligandsare essentially fungibleandcanbeexchangedatvarioustimestoconferthedesiredproperties to theparticle.Thiscanincludeprotectingtheparticlefromharshaqueousconditions,such as pHextremes,maximizingopticalpropertiesfordiagnosticsorshieldingtheparticlefrom potentially hostileconditionsfoundinthebody.Becausethesemoietiesinteractubiquitously with variousbiologicalmaterials,particularlyproteins,thereneedstobearationalizeddesign of surfaceligands.Thedesignoftheligandcanhavecrucialeffectsonbiodistributionaswell as evasionofbiologicaldefenses.Ligandscanevenbedesignedtoprovidenewfunctionality in responsetovariousenvironmentalstimulitoimprovetheirtherapeuticordiagnosticcapa- bilities. Consideringtheimportanceofligandsthenonthisemergingfield,thisreviewwill thoroughly considertheliganddesignforthevariousstepsofnanodevelopment,fromsynthesis and assemblythroughbiomedicaltranslation. © 2014ElsevierLtd.Allrightsreserved. | - |
dc.description.uri | 1 | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | Ligand | - |
dc.subject | Nanoparticle | - |
dc.subject | Assembly | - |
dc.subject | Surface modification | - |
dc.subject | Nanomedicine | - |
dc.title | Surface ligands in synthesis, modification, assembly and biomedical applications of nanoparticles | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.identifier.wosid | 000342533000008 | - |
dc.identifier.scopusid | 2-s2.0-84910014159 | - |
dc.identifier.rimsid | 16411 | ko |
dc.date.tcdate | 2018-10-01 | - |
dc.contributor.affiliatedAuthor | Daishun Ling | - |
dc.contributor.affiliatedAuthor | Michael J. Hackett | - |
dc.contributor.affiliatedAuthor | Taeg Hwan Hyeon | - |
dc.identifier.doi | 10.1016/j.nantod.2014.06.005 | - |
dc.identifier.bibliographicCitation | NANO TODAY, v.9, no.4, pp.457 - 477 | - |
dc.citation.title | NANO TODAY | - |
dc.citation.volume | 9 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 457 | - |
dc.citation.endPage | 477 | - |
dc.date.scptcdate | 2018-10-01 | - |
dc.description.wostc | 71 | - |
dc.description.scptc | 76 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | FUNCTIONALIZED GOLD NANOPARTICLES | - |
dc.subject.keywordPlus | IRON-OXIDE NANOPARTICLES | - |
dc.subject.keywordPlus | ACCELERATED BLOOD CLEARANCE | - |
dc.subject.keywordPlus | SEMICONDUCTOR QUANTUM DOTS | - |
dc.subject.keywordPlus | AMPHIPHILIC TRIBLOCK COPOLYMERS | - |
dc.subject.keywordPlus | CORE-SHELL NANOPARTICLES | - |
dc.subject.keywordPlus | TARGETED DRUG-DELIVERY | - |
dc.subject.keywordPlus | IMAGING IN-VIVO | - |
dc.subject.keywordPlus | CDSE NANOCRYSTALS | - |
dc.subject.keywordPlus | CONTRAST AGENTS | - |
dc.subject.keywordAuthor | Ligand | - |
dc.subject.keywordAuthor | Nanoparticle | - |
dc.subject.keywordAuthor | Assembly | - |
dc.subject.keywordAuthor | Surface modification | - |
dc.subject.keywordAuthor | Nanomedicine | - |