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나노입자 연구단
나노입자 연구단
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Dynamic Contrast-Enhanced MR Imaging of Nonenhancing T2 High-Signal-Intensity Lesions in Baseline and Posttreatment Glioblastoma: Temporal Change and Prognostic Value

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Title
Dynamic Contrast-Enhanced MR Imaging of Nonenhancing T2 High-Signal-Intensity Lesions in Baseline and Posttreatment Glioblastoma: Temporal Change and Prognostic Value
Author(s)
I. Hwang; S.H. Choi; Park C.-K.; Kim T.M.; Park S.-H.; Won J.K.; Kim I.H.; Lee S.-T.; R.-E. Yoo; K.M. Kang; T.J. Yun; J.-H. Kim; C.-H. Sohn
Publication Date
2020-01
Journal
AMERICAN JOURNAL OF NEURORADIOLOGY, v.41, no.1, pp.49 - 56
Publisher
AMER SOC NEURORADIOLOGY
Abstract
© 2020 by American Journal of Neuroradiology.BACKGROUND AND PURPOSE: The prognostic value of dynamic contrast-enhanced MR imaging on nonenhancing T2 high-signal-intensity lesions in patients with glioblastoma has not been thoroughly elucidated to date. We evaluated the temporal change and prognostic value for progression-free survival of dynamic contrast-enhanced MR imaging-derived pharmacokinetic parameters on nonenhancing T2 high-signal-intensity lesions in patients with glioblastoma before and after standard treatment, including gross total surgical resection. MATERIALS AND METHODS: This retrospective study included 33 patients who were newly diagnosed with glioblastoma and treated with gross total surgical resection followed by concurrent chemoradiation therapy and adjuvant chemotherapy with temozolomide in a single institution. All patients underwent dynamic contrast-enhanced MR imaging before surgery as a baseline and after completion of maximal surgical resection and concurrent chemoradiation therapy. On the whole nonenhancing T2 high-signal-intensity lesion, dynamic contrast-enhanced MR imaging-derived pharmacokinetic parameters (volume transfer constant [Ktrans], volume of extravascular extracellular space [ve], and blood plasma volume [vp ]) were calculated. The Cox proportional hazards regression model analysis was performed to determine the histogram features or percentage changes of pharmacokinetic parameters related to progression-free survival. RESULTS: Baseline median Ktrans, baseline first quartile Ktrans, and posttreatment median Ktrans were significant independent variables, as determined by univariate analysis (P < .05). By multivariate Cox regression analysis including methylation status of O6-methylguanine-DNA methyltransferase, baseline median Ktrans was determined to be the significant independent variable and was negatively related to progression-free survival (hazard ratio = 1.48, P = .003). CONCLUSIONS: Baseline median Ktrans from nonenhancing T2 high-signal-intensity lesions could be a potential prognostic imaging biomarker in patients undergoing gross total surgical resection followed by standard therapy for glioblastoma
URI
https://pr.ibs.re.kr/handle/8788114/7262
ISSN
0195-6108
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Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
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