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Dynamic Contrast-Enhanced MR Imaging of Nonenhancing T2 High-Signal-Intensity Lesions in Baseline and Posttreatment Glioblastoma: Temporal Change and Prognostic Value

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dc.contributor.authorI. Hwang-
dc.contributor.authorS.H. Choi-
dc.contributor.authorPark C.-K.-
dc.contributor.authorKim T.M.-
dc.contributor.authorPark S.-H.-
dc.contributor.authorWon J.K.-
dc.contributor.authorKim I.H.-
dc.contributor.authorLee S.-T.-
dc.contributor.authorR.-E. Yoo-
dc.contributor.authorK.M. Kang-
dc.contributor.authorT.J. Yun-
dc.contributor.authorJ.-H. Kim-
dc.contributor.authorC.-H. Sohn-
dc.date.available2020-10-14T08:15:28Z-
dc.date.created2020-02-17-
dc.date.issued2020-01-
dc.identifier.issn0195-6108-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/7262-
dc.description.abstract© 2020 by American Journal of Neuroradiology.BACKGROUND AND PURPOSE: The prognostic value of dynamic contrast-enhanced MR imaging on nonenhancing T2 high-signal-intensity lesions in patients with glioblastoma has not been thoroughly elucidated to date. We evaluated the temporal change and prognostic value for progression-free survival of dynamic contrast-enhanced MR imaging-derived pharmacokinetic parameters on nonenhancing T2 high-signal-intensity lesions in patients with glioblastoma before and after standard treatment, including gross total surgical resection. MATERIALS AND METHODS: This retrospective study included 33 patients who were newly diagnosed with glioblastoma and treated with gross total surgical resection followed by concurrent chemoradiation therapy and adjuvant chemotherapy with temozolomide in a single institution. All patients underwent dynamic contrast-enhanced MR imaging before surgery as a baseline and after completion of maximal surgical resection and concurrent chemoradiation therapy. On the whole nonenhancing T2 high-signal-intensity lesion, dynamic contrast-enhanced MR imaging-derived pharmacokinetic parameters (volume transfer constant [Ktrans], volume of extravascular extracellular space [ve], and blood plasma volume [vp ]) were calculated. The Cox proportional hazards regression model analysis was performed to determine the histogram features or percentage changes of pharmacokinetic parameters related to progression-free survival. RESULTS: Baseline median Ktrans, baseline first quartile Ktrans, and posttreatment median Ktrans were significant independent variables, as determined by univariate analysis (P < .05). By multivariate Cox regression analysis including methylation status of O6-methylguanine-DNA methyltransferase, baseline median Ktrans was determined to be the significant independent variable and was negatively related to progression-free survival (hazard ratio = 1.48, P = .003). CONCLUSIONS: Baseline median Ktrans from nonenhancing T2 high-signal-intensity lesions could be a potential prognostic imaging biomarker in patients undergoing gross total surgical resection followed by standard therapy for glioblastoma-
dc.description.uri1-
dc.language영어-
dc.publisherAMER SOC NEURORADIOLOGY-
dc.titleDynamic Contrast-Enhanced MR Imaging of Nonenhancing T2 High-Signal-Intensity Lesions in Baseline and Posttreatment Glioblastoma: Temporal Change and Prognostic Value-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000508565000011-
dc.identifier.scopusid2-s2.0-85077782735-
dc.identifier.rimsid71202-
dc.contributor.affiliatedAuthorI. Hwang-
dc.contributor.affiliatedAuthorS.H. Choi-
dc.contributor.affiliatedAuthorR.-E. Yoo-
dc.contributor.affiliatedAuthorK.M. Kang-
dc.contributor.affiliatedAuthorT.J. Yun-
dc.contributor.affiliatedAuthorJ.-H. Kim-
dc.contributor.affiliatedAuthorC.-H. Sohn-
dc.identifier.doi10.3174/ajnr.A6323-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF NEURORADIOLOGY, v.41, no.1, pp.49 - 56-
dc.citation.titleAMERICAN JOURNAL OF NEURORADIOLOGY-
dc.citation.volume41-
dc.citation.number1-
dc.citation.startPage49-
dc.citation.endPage56-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
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Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
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