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인지 및 사회성 연구단
인지 및 사회성 연구단
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Ultrasonic Neuromodulation via Astrocytic TRPA1

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Title
Ultrasonic Neuromodulation via Astrocytic TRPA1
Author(s)
Soo-Jin Oh; Jung Moo Lee; Hyun-Bum Kim; Jungpyo Lee; Sungmin Han; Jin Young Bae; Gyu-Sang Hong; Wuhyun Koh; Jea Kwon; Eun-Sang Hwang; Dong Ho Woo; Inchan Youn; Il-Joo Cho; Yong Chul Bae; Sungon Lee; Jae Wan Shim; Ji-Ho Park; C. Justin Lee
Publication Date
2019-10
Journal
CURRENT BIOLOGY, v.29, no.20, pp.3386 - +
Publisher
CELL PRESS
Abstract
Low-intensity, low-frequency ultrasound (LILFU) is the next-generation, non-invasive brain stimulation technology for treating various neurological and psychiatric disorders. However, the underlying cellular and molecular mechanism of LILFU-induced neuromodulation has remained unknown. Here, we report that LILFU-induced neuromodulation is initiated by opening of TRPA1 channels in astrocytes. The Ca2+ entry through TRPA1 causes a release of gliotransmitters including glutamate through Best1 channels in astrocytes. The released glutamate activates NMDA receptors in neighboring neurons to elicit action potential firing. Our results reveal an unprecedented mechanism of LILFU-induced neuromodulation, involving TRPA1 as a unique sensor for LILFU and glutamate-releasing Best1 as a mediator of glia-neuron interaction. These discoveries should prove to be useful for optimization of human brain stimulation and ultrasonogenetic manipulations of TRPA1. c. 2019 Elsevier Ltd.
URI
https://pr.ibs.re.kr/handle/8788114/6831
ISSN
0960-9822
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > Cognitive Glioscience Group(인지 교세포과학 그룹) > Journal Papers (저널논문)
Center for Cognition and Sociality(인지 및 사회성 연구단) > Journal Papers (저널논문)
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