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Bioresorbable Electronic Implants: History, Materials, Fabrication, Devices, and Clinical Applications

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Title
Bioresorbable Electronic Implants: History, Materials, Fabrication, Devices, and Clinical Applications
Author(s)
Gi Doo Cha; Dayoung Kang; Jongha Lee; Dae-Hyeong Kim
Publication Date
2019-06
Journal
ADVANCED HEALTHCARE MATERIALS, v.8, no.11, pp.1801660 -
Publisher
WILEY
Abstract
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Medical implants, either passive implants for structural support or implantable devices with active electronics, have been widely used for the diagnosis and treatment of various diseases and clinical issues. These implants offer various functions, including mechanical support of biological structures in orthopedic and dental applications, continuous electrophysiological monitoring and feedback of electrical stimulation in neuronal and cardiac applications, and controlled drug delivery while maintaining arterial structure in drug-eluting stents. Although these implants exhibit long-term biocompatibility, surgery for their retrieval is often required, which imposes physical, biological, and economical burdens on the patients. Therefore, as an alternative to such secondary surgeries, bioresorbable implants that disappear after a certain period of time inside the body, including bioresorbable active electronics, have been highlighted recently. This review first discusses the historical background of medical implants and briefly define related terminology. Representative examples of non-degradable medical implants for passive structural support and/or for diagnosis and therapy with active electronics are also provided. Then, recent progress in bioresorbable active implants composed of biosignal sensors, actuators for therapeutics, wireless power supply components, and their integrated systems are reviewed. Finally, clinical applications of these bioresorbable electronic implants are exemplified with brief conclusion and future outlook
URI
https://pr.ibs.re.kr/handle/8788114/6587
ISSN
2192-2640
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
Files in This Item:
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