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Food antigens drive spontaneous IgE elevation in the absence of commensal microbiota

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Title
Food antigens drive spontaneous IgE elevation in the absence of commensal microbiota
Author(s)
Sung-Wook Hong; Eunju O.; Jun Young Lee; Minji Lee; Daehee Han; Hyun-Ja Ko; Sprent J.; Charles D. Surh; Kwang Soon Kim
Publication Date
2019-05
Journal
SCIENCE ADVANCES, v.5, no.5, pp.eaaw1507 -
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Abstract
© 2019 by the Authors.Immunoglobulin E (IgE), a key mediator in allergic diseases, is spontaneously elevated in mice with disrupted commensal microbiota such as germ-free (GF) and antibiotics-treated mice. However, the underlying mechanisms for aberrant IgE elevation are still unclear. Here, we demonstrate that food antigens drive spontaneous IgE elevation in GF and antibiotics-treated mice by generating T helper 2 (TH2)-skewed T follicular helper (TFH) cells in gutassociated lymphoid tissues (GALTs). In these mice, depriving contact with food antigens results in defective IgE elevation as well as impaired generation of TFH cells and IgE-producing cells in GALT. Food antigen-driven TFH cells in GF mice are mostly generated in early life, especially during the weaning period. We also reveal that food antigen-driven TFH cells in GF mice are actively depleted by colonization with commensal microbiota. Thus, our findings provide a possible explanation for why the perturbation of commensal microbiota in early life increases the occurrence of allergic diseases
URI
https://pr.ibs.re.kr/handle/8788114/6309
ISSN
2375-2548
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
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