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면역미생물공생연구단
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Food antigens drive spontaneous IgE elevation in the absence of commensal microbiota

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dc.contributor.authorSung-Wook Hong-
dc.contributor.authorEunju O.-
dc.contributor.authorJun Young Lee-
dc.contributor.authorMinji Lee-
dc.contributor.authorDaehee Han-
dc.contributor.authorHyun-Ja Ko-
dc.contributor.authorSprent J.-
dc.contributor.authorCharles D. Surh-
dc.contributor.authorKwang Soon Kim-
dc.date.available2019-10-11T08:10:13Z-
dc.date.created2019-06-17-
dc.date.issued2019-05-
dc.identifier.issn2375-2548-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/6309-
dc.description.abstract© 2019 by the Authors.Immunoglobulin E (IgE), a key mediator in allergic diseases, is spontaneously elevated in mice with disrupted commensal microbiota such as germ-free (GF) and antibiotics-treated mice. However, the underlying mechanisms for aberrant IgE elevation are still unclear. Here, we demonstrate that food antigens drive spontaneous IgE elevation in GF and antibiotics-treated mice by generating T helper 2 (TH2)-skewed T follicular helper (TFH) cells in gutassociated lymphoid tissues (GALTs). In these mice, depriving contact with food antigens results in defective IgE elevation as well as impaired generation of TFH cells and IgE-producing cells in GALT. Food antigen-driven TFH cells in GF mice are mostly generated in early life, especially during the weaning period. We also reveal that food antigen-driven TFH cells in GF mice are actively depleted by colonization with commensal microbiota. Thus, our findings provide a possible explanation for why the perturbation of commensal microbiota in early life increases the occurrence of allergic diseases-
dc.description.uri1-
dc.language영어-
dc.publisherAMER ASSOC ADVANCEMENT SCIENCE-
dc.titleFood antigens drive spontaneous IgE elevation in the absence of commensal microbiota-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000470125000096-
dc.identifier.scopusid2-s2.0-85066319689-
dc.identifier.rimsid68389-
dc.contributor.affiliatedAuthorSung-Wook Hong-
dc.contributor.affiliatedAuthorEunju O.-
dc.contributor.affiliatedAuthorJun Young Lee-
dc.contributor.affiliatedAuthorMinji Lee-
dc.contributor.affiliatedAuthorDaehee Han-
dc.contributor.affiliatedAuthorHyun-Ja Ko-
dc.contributor.affiliatedAuthorCharles D. Surh-
dc.contributor.affiliatedAuthorKwang Soon Kim-
dc.identifier.doi10.1126/sciadv.aaw1507-
dc.identifier.bibliographicCitationSCIENCE ADVANCES, v.5, no.5, pp.eaaw1507-
dc.citation.titleSCIENCE ADVANCES-
dc.citation.volume5-
dc.citation.number5-
dc.citation.startPageeaaw1507-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > 1. Journal Papers (저널논문)
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
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