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Steve Granick
첨단연성물질 연구단
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Single-crosslink microscopy in a biopolymer network dissects local elasticity from molecular fluctuations

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Title
Single-crosslink microscopy in a biopolymer network dissects local elasticity from molecular fluctuations
Author(s)
Jiang, LX; Xie, QQ; Tsang, B; Steve Granick
Publication Date
2019-07
Journal
NATURE COMMUNICATIONS, v.10, no., pp.3314 -
Publisher
NATURE PUBLISHING GROUP
Abstract
Polymer networks are fundamental from cellular biology to plastics technology but their intrinsic inhomogeneity is masked by the usual ensemble-averaged measurements. Here, we construct direct maps of crosslinks-symbolic depiction of spatially-distributed elements highlighting their physical features and the relationships between them-in an actin network. We selectively label crosslinks with fluorescent markers, track their thermal fluctuations, and characterize the local elasticity and cross-correlations between crosslinks. Such maps display massive heterogeneity, reveal abundant anticorrelations, and may contribute to address how local responses scale up to produce macroscopic elasticity. Single-crosslink microscopy offers a general, microscopic framework to better understand crosslinked molecular networks in undeformed or strained states.
URI
https://pr.ibs.re.kr/handle/8788114/6300
ISSN
2041-1723
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > Journal Papers (저널논문)
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