Single-crosslink microscopy in a biopolymer network dissects local elasticity from molecular fluctuations
DC Field | Value | Language |
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dc.contributor.author | Jiang, LX | - |
dc.contributor.author | Xie, QQ | - |
dc.contributor.author | Tsang, B | - |
dc.contributor.author | Steve Granick | - |
dc.date.available | 2019-10-11T08:09:04Z | - |
dc.date.created | 2019-08-20 | - |
dc.date.issued | 2019-07 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://pr.ibs.re.kr/handle/8788114/6300 | - |
dc.description.abstract | Polymer networks are fundamental from cellular biology to plastics technology but their intrinsic inhomogeneity is masked by the usual ensemble-averaged measurements. Here, we construct direct maps of crosslinks-symbolic depiction of spatially-distributed elements highlighting their physical features and the relationships between them-in an actin network. We selectively label crosslinks with fluorescent markers, track their thermal fluctuations, and characterize the local elasticity and cross-correlations between crosslinks. Such maps display massive heterogeneity, reveal abundant anticorrelations, and may contribute to address how local responses scale up to produce macroscopic elasticity. Single-crosslink microscopy offers a general, microscopic framework to better understand crosslinked molecular networks in undeformed or strained states. | - |
dc.description.uri | 1 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Single-crosslink microscopy in a biopolymer network dissects local elasticity from molecular fluctuations | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.identifier.wosid | 000477017300003 | - |
dc.identifier.scopusid | 2-s2.0-85070611899 | - |
dc.identifier.rimsid | 69472 | - |
dc.contributor.affiliatedAuthor | Steve Granick | - |
dc.identifier.doi | 10.1038/s41467-019-11313-7 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.10, pp.3314 | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 10 | - |
dc.citation.startPage | 3314 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | DYNAMICS | - |
dc.subject.keywordPlus | MICRORHEOLOGY | - |
dc.subject.keywordPlus | MECHANICS | - |