Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target

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Title
Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target
Author(s)
Park S.-J.; Kim B.; Choi S.; Balasubramaniam S.; Lee S.-C.; Lee J.Y.; Kim H.S.; Kim J.-Y.; Jong-Jin Kim; Lee Y.-A.; Kang N.-Y.; Jin-Soo Kim; Young-Tae Chang
Publication Date
2019-03
Journal
NATURE COMMUNICATIONS, v.10, no.1, pp.1111 -
Publisher
NATURE PUBLISHING GROUP
Abstract
Activated macrophages have the potential to be ideal targets for imaging inflammation. However, probe selectivity over non-activated macrophages and probe delivery to target tissue have been challenging. Here, we report a small molecule probe specific for activated macrophages, called CDg16, and demonstrate its application to visualizing inflammatory atherosclerotic plaques in vivo. Through a systematic transporter screen using a CRISPR activation library, we identify the orphan transporter Slc18b1/SLC18B1 as the gating target of CDg16. © 2019, The Author(s)
URI
https://pr.ibs.re.kr/handle/8788114/5669
ISSN
2041-1723
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
Center for Genome Engineering(유전체 교정 연구단) > Journal Papers (저널논문)
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