Large‐Scale Synthesis and Medical Applications of Uniform‐Sized Metal Oxide Nanoparticles

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Title
Large‐Scale Synthesis and Medical Applications of Uniform‐Sized Metal Oxide Nanoparticles
Author(s)
Hyek Jin Kwon; Kwangsoo Shin; Min Soh; Hogeun Chang; Jonghoon Kim; Jisoo Lee; Giho Ko; Byung Hyo Kim; Dokyoon Kim; Taeghwan Hyeon
Publication Date
2018-10
Journal
ADVANCED MATERIALS, v.30, no.42, pp.1704290 -
Publisher
WILEY-V C H VERLAG GMBH
Abstract
Thanks to recent advances in the synthesis of high-quality inorganic nanoparticles, more and more types of nanoparticles are becoming available for medical applications. Especially, metal oxide nanoparticles have drawn much attention due to their unique physicochemical properties and relatively inexpensive production costs. To further promote the development and clinical translation of these nanoparticle-based agents, however, it is highly desirable to reduce unwanted interbatch variations of the nanoparticles because characterizing and refining each batch are costly, take a lot of effort, and, thus, are not productive. Large-scale synthesis is a straightforward and economic pathway to minimize this issue. Here, the recent achievements in the large-scale synthesis of uniform-sized metal oxide nanoparticles and their biomedical applications are summarized, with a focus on nanoparticles of transition metal oxides and lanthanide oxides, and clarifying the underlying mechanism for the synthesis of uniform-sized nanoparticles. Surface modification steps to endow hydrophobic nanoparticles with water dispersibility and biocompatibility are also briefly described. Finally, various medical applications of metal oxide nanoparticles, such as bioimaging, drug delivery, and therapy, are presented.© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
URI
https://pr.ibs.re.kr/handle/8788114/5425
ISSN
0935-9648
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
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