BROWSE

Related Scientist

Researcher

나노입자 연구단
나노입자 연구단
more info

Biocompatible custom ceria nanoparticles against reactive oxygen species resolve acute inflammatory reaction after intracerebral hemorrhage

Cited 4 time in webofscience Cited 0 time in scopus
93 Viewed 8 Downloaded
Title
Biocompatible custom ceria nanoparticles against reactive oxygen species resolve acute inflammatory reaction after intracerebral hemorrhage
Author(s)
Dong-Wan Kang; Chi Kyung Kim; Han-Gil Jeong; Min Soh; Taeho Kim; In-Young Choi; Seul-Ki Ki; Do Yeon Kim; Wookjin Yang; Taeghwan Hyeon; Seung-Hoon Lee
Publication Date
2017-08
Journal
Nano Research, v.10, no.8, pp.2743 - 2760
Publisher
TSINGHUA UNIV PRESS
Abstract
Intracerebral hemorrhage (ICH) is a devastating subtype of stroke with a high mortality rate, for which there currently is no effective treatment. A perihematomal edema caused by an intense inflammatory reaction is more deleterious than the hematoma itself and can result in neurological deterioration and death. Ceria nanoparticles (CeNPs) are potent free radical scavengers with potential for biomedical applications. As oxidative stress plays a major role in post-ICH inflammation, we hypothesized that CeNPs might protect against ICH. To test this hypothesis, core CeNPs were synthesized using a modified reverse micelle method and covered with phospholipid-polyethylene glycol (PEG) to achieve biocompatibility. We investigated whether our custom-made biocompatible CeNPs have protective effects against ICH. The CeNPs reduced oxidative stress, hemin-induced cytotoxicity, and inflammation in vitro. In a rodent ICH model, intravenously administered CeNPs were mainly distributed in the hemorrhagic hemisphere, suggesting that they could diffuse through the damaged blood–brain barrier. Moreover, CeNPs attenuated microglia/macrophage recruitment around the hemorrhagic lesion and inflammatory protein expression. Finally, CeNP treatment reduced the brain edema by 68.4% as compared to the control. These results reveal the great potential of CeNPs as a novel therapeutic agent for patients with ICH. © Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2017
URI
https://pr.ibs.re.kr/handle/8788114/4349
ISSN
1998-0124
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
Files in This Item:
03.biocompatible custom.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse