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Biocompatible custom ceria nanoparticles against reactive oxygen species resolve acute inflammatory reaction after intracerebral hemorrhage

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dc.contributor.authorDong-Wan Kang-
dc.contributor.authorChi Kyung Kim-
dc.contributor.authorHan-Gil Jeong-
dc.contributor.authorMin Soh-
dc.contributor.authorTaeho Kim-
dc.contributor.authorIn-Young Choi-
dc.contributor.authorSeul-Ki Ki-
dc.contributor.authorDo Yeon Kim-
dc.contributor.authorWookjin Yang-
dc.contributor.authorTaeghwan Hyeon-
dc.contributor.authorSeung-Hoon Lee-
dc.date.available2018-02-09T01:10:40Z-
dc.date.created2018-02-06-
dc.date.issued2017-08-
dc.identifier.issn1998-0124-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/4349-
dc.description.abstractIntracerebral hemorrhage (ICH) is a devastating subtype of stroke with a high mortality rate, for which there currently is no effective treatment. A perihematomal edema caused by an intense inflammatory reaction is more deleterious than the hematoma itself and can result in neurological deterioration and death. Ceria nanoparticles (CeNPs) are potent free radical scavengers with potential for biomedical applications. As oxidative stress plays a major role in post-ICH inflammation, we hypothesized that CeNPs might protect against ICH. To test this hypothesis, core CeNPs were synthesized using a modified reverse micelle method and covered with phospholipid-polyethylene glycol (PEG) to achieve biocompatibility. We investigated whether our custom-made biocompatible CeNPs have protective effects against ICH. The CeNPs reduced oxidative stress, hemin-induced cytotoxicity, and inflammation in vitro. In a rodent ICH model, intravenously administered CeNPs were mainly distributed in the hemorrhagic hemisphere, suggesting that they could diffuse through the damaged blood–brain barrier. Moreover, CeNPs attenuated microglia/macrophage recruitment around the hemorrhagic lesion and inflammatory protein expression. Finally, CeNP treatment reduced the brain edema by 68.4% as compared to the control. These results reveal the great potential of CeNPs as a novel therapeutic agent for patients with ICH. © Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2017-
dc.description.uri1-
dc.language영어-
dc.publisherTSINGHUA UNIV PRESS-
dc.subjectceria nanoparticles,-
dc.subjectintracerebral hemorrhage,-
dc.subjectfree radical injury,-
dc.subjectanti-inflammation,-
dc.subjectneuroprotective agents,-
dc.subjectbiomedical application-
dc.titleBiocompatible custom ceria nanoparticles against reactive oxygen species resolve acute inflammatory reaction after intracerebral hemorrhage-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000404560100018-
dc.identifier.scopusid2-s2.0-85017586114-
dc.identifier.rimsid62155ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorMin Soh-
dc.contributor.affiliatedAuthorTaeho Kim-
dc.contributor.affiliatedAuthorTaeghwan Hyeon-
dc.identifier.doi10.1007/s12274-017-1478-6-
dc.identifier.bibliographicCitationNANO RESEARCH, v.10, no.8, pp.2743 - 2760-
dc.citation.titleNANO RESEARCH-
dc.citation.volume10-
dc.citation.number8-
dc.citation.startPage2743-
dc.citation.endPage2760-
dc.date.scptcdate2018-10-01-
dc.description.wostc4-
dc.description.scptc4-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
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