Iron oxide nanoclusters for T 1 magnetic resonance imaging of non-human primates

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Title
Iron oxide nanoclusters for T 1 magnetic resonance imaging of non-human primates
Author(s)
Yang Lu; Yun-Jun Xu; Guo-bing Zhang; Daishun Ling; Ming-quan Wang; Yong Zhou; Ya-Dong Wu; Tao Wu; Michael J. Hackett; Byung Hyo Kim; Hogeun Chang; Jonghoon Kim; Xin-Tian Hu; Liang Dong; Nohyun Lee; Fangyuan Li; Jia-Cai He; Li Zhang; Hui-Qin Wen; Bo Yang; Seung Hong Choi; Taeghwan Hyeon; Duo-Hong Zou
Publication Date
2017-08
Journal
Nature Biomedical Engineering, v.1, no.8, pp.637 - 643
Publisher
Nature Publishing Group
Abstract
Iron-oxide-based contrast agents for magnetic resonance imaging (MRI) had been clinically approved in the United States and Europe, yet most of these nanoparticle products were discontinued owing to failures to meet rigorous clinical requirements. Significant advances have been made in the synthesis of magnetic nanoparticles and their biomedical applications, but several major challenges remain for their clinical translation, in particular large-scale and reproducible synthesis, systematic toxicity assessment, and their preclinical evaluation in MRI of large animals. Here, we report the results of a toxicity study of iron oxide nanoclusters of uniform size in large animal models, including beagle dogs and the more clinically relevant macaques. We also show that iron oxide nanoclusters can be used as T 1 MRI contrast agents for high-resolution magnetic resonance angiography in beagle dogs and macaques, and that dynamic MRI enables the detection of cerebral ischaemia in these large animals. Iron oxide nanoclusters show clinical potential as next-generation MRI contrast agents. © 2017 The Author(s)
URI
https://pr.ibs.re.kr/handle/8788114/4241
ISSN
2157-846X
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
Files in This Item:
국내-02.Iron Oxide Nanoclusters.pdfDownload

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