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Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module Highly Cited Paper

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Title
Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module
Author(s)
Hyunjae Lee; Changyeong Song; Yong Seok Hong; Min Sung Kim; Hye Rim Cho; Taegyu Kang; Kwangsoo Shin; Seung Hong Choi; Taeghwan Hyeon; Dae-Hyeong Kim
Publication Date
2017-03
Journal
SCIENCE ADVANCES, v.3, no.3, pp.e1601314 -
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Abstract
Electrochemical analysis of sweat using soft bioelectronics on human skin provides a new route for noninvasive glucose monitoring without painful blood collection. However, sweat-based glucose sensing still faces many challenges, such as difficulty in sweat collection, activity variation of glucose oxidase due to lactic acid secretion and ambient temperature changes, and delamination of the enzyme when exposed to mechanical friction and skin deformation. Precise point-of-care therapy in response to the measured glucose levels is still very challenging. We present a wearable/disposable sweat-based glucose monitoring device integrated with a feedback transdermal drug delivery module. Careful multilayer patch design and miniaturization of sensors increase the efficiency of the sweat collection and sensing process. Multimodal glucose sensing, as well as its real-time correction based on pH, temperature, and humidity measurements, maximizes the accuracy of the sensing. The minimal layout design of the same sensors also enables a strip-type disposable device. Drugs for the feedback transdermal therapy are loaded on two different temperature-responsive phase change nanoparticles. These nanoparticles are embedded in hyaluronic acid hydrogel microneedles, which are additionally coated with phase change materials. This enables multistage, spatially patterned, and precisely controlled drug release in response to the patient’s glucose level. The system provides a novel closed-loop solution for the noninvasive sweat-based management of diabetes mellitus. 2017 © The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
URI
http://pr.ibs.re.kr/handle/8788114/3442
DOI
10.1126/sciadv.1601314
ISSN
2375-2548
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
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