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Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery moduleHighly Cited Paper

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dc.contributor.authorHyunjae Lee-
dc.contributor.authorChangyeong Song-
dc.contributor.authorYong Seok Hong-
dc.contributor.authorMin Sung Kim-
dc.contributor.authorHye Rim Cho-
dc.contributor.authorTaegyu Kang-
dc.contributor.authorKwangsoo Shin-
dc.contributor.authorSeung Hong Choi-
dc.contributor.authorTaeghwan Hyeon-
dc.contributor.authorDae-Hyeong Kim-
dc.date.available2017-05-19T01:12:28Z-
dc.date.created2017-04-05ko
dc.date.issued2017-03-
dc.identifier.issn2375-2548-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/3442-
dc.description.abstractElectrochemical analysis of sweat using soft bioelectronics on human skin provides a new route for noninvasive glucose monitoring without painful blood collection. However, sweat-based glucose sensing still faces many challenges, such as difficulty in sweat collection, activity variation of glucose oxidase due to lactic acid secretion and ambient temperature changes, and delamination of the enzyme when exposed to mechanical friction and skin deformation. Precise point-of-care therapy in response to the measured glucose levels is still very challenging. We present a wearable/disposable sweat-based glucose monitoring device integrated with a feedback transdermal drug delivery module. Careful multilayer patch design and miniaturization of sensors increase the efficiency of the sweat collection and sensing process. Multimodal glucose sensing, as well as its real-time correction based on pH, temperature, and humidity measurements, maximizes the accuracy of the sensing. The minimal layout design of the same sensors also enables a strip-type disposable device. Drugs for the feedback transdermal therapy are loaded on two different temperature-responsive phase change nanoparticles. These nanoparticles are embedded in hyaluronic acid hydrogel microneedles, which are additionally coated with phase change materials. This enables multistage, spatially patterned, and precisely controlled drug release in response to the patient’s glucose level. The system provides a novel closed-loop solution for the noninvasive sweat-based management of diabetes mellitus. 2017 © The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).-
dc.description.uri1-
dc.language영어-
dc.publisherAMER ASSOC ADVANCEMENT SCIENCE-
dc.titleWearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000397044000018-
dc.identifier.scopusid2-s2.0-85041738561-
dc.identifier.rimsid59127ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorHyunjae Lee-
dc.contributor.affiliatedAuthorChangyeong Song-
dc.contributor.affiliatedAuthorYong Seok Hong-
dc.contributor.affiliatedAuthorMin Sung Kim-
dc.contributor.affiliatedAuthorHye Rim Cho-
dc.contributor.affiliatedAuthorTaegyu Kang-
dc.contributor.affiliatedAuthorKwangsoo Shin-
dc.contributor.affiliatedAuthorSeung Hong Choi-
dc.contributor.affiliatedAuthorTaeghwan Hyeon-
dc.contributor.affiliatedAuthorDae-Hyeong Kim-
dc.identifier.doi10.1126/sciadv.1601314-
dc.identifier.bibliographicCitationSCIENCE ADVANCES, v.3, no.3, pp.e1601314-
dc.citation.titleSCIENCE ADVANCES-
dc.citation.volume3-
dc.citation.number3-
dc.citation.startPagee1601314-
dc.date.scptcdate2018-10-01-
dc.description.wostc70-
dc.description.scptc74-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
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