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복잡계 자기조립 연구단
복잡계 자기조립 연구단
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Light-Induced Acid Generation on a Gatekeeper for Smart Nitric Oxide Delivery

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Title
Light-Induced Acid Generation on a Gatekeeper for Smart Nitric Oxide Delivery
Author(s)
Hyung Woo Choi; Jihoon Kim; Kim J.; Yonghwi Kim; Song H.B.; Kim J.H.; Kimoon Kim; Won Jong Kim
Publication Date
2016-04
Journal
ACS NANO, v.10, no.4, pp.4199 - 4208
Publisher
AMER CHEMICAL SOC
Abstract
We report herein the design of a light-responsive gatekeeper for smart nitric oxide (NO) delivery. The gatekeeper is composed of a pH-jump reagent as an intermediary of stimulus and a calcium phosphate (CaP) coating as a shielding layer for NO release. The light irradiation and subsequent acid generation are used as triggers for uncapping the gatekeeper and releasing NO. The acids generated from a light-activated pH-jump agent loaded in the mesoporous nanoparticles accelerated the degradation of the CaP-coating layers on the nanoparticles, facilitating the light-responsive NO release from diazeniumdiolate by exposing a NO donor to physiological conditions. Using the combination of the pH-jump reagent and CaP coating, we successfully developed a light-responsive gatekeeper system for spatiotemporal-controlled NO delivery. © 2016 American Chemical Society
URI
https://pr.ibs.re.kr/handle/8788114/2679
ISSN
1936-0851
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
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