IBS Publications Repository: Light-Induced Acid Generation on a Gatekeeper for Smart Nitric Oxide Delivery

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Light-Induced Acid Generation on a Gatekeeper for Smart Nitric Oxide Delivery

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Title: Light-Induced Acid Generation on a Gatekeeper for Smart Nitric Oxide Delivery

Author(s): Hyung Woo Choi; Jihoon Kim; Kim J.; Yonghwi Kim; Song H.B.; Kim J.H.; Kimoon Kim; Won Jong Kim

Subject: calcium phosphate, ; corneal wound healing, ; gatekeeper, ; nitric oxide delivery, ; pH-jump reagent

Abstract: We report herein the design of a light-responsive gatekeeper for smart nitric oxide (NO) delivery. The gatekeeper is composed of a pH-jump reagent as an intermediary of stimulus and a calcium phosphate (CaP) coating as a shielding layer for NO release. The light irradiation and subsequent acid generation are used as triggers for uncapping the gatekeeper and releasing NO. The acids generated from a light-activated pH-jump agent loaded in the mesoporous nanoparticles accelerated the degradation of the CaP-coating layers on the nanoparticles, facilitating the light-responsive NO release from diazeniumdiolate by exposing a NO donor to physiological conditions. Using the combination of the pH-jump reagent and CaP coating, we successfully developed a light-responsive gatekeeper system for spatiotemporal-controlled NO delivery. © 2016 American Chemical Society