BROWSE

Related Scientist

csc's photo.

csc
복잡계자기조립연구단
more info

ITEM VIEW & DOWNLOAD

Light-Induced Acid Generation on a Gatekeeper for Smart Nitric Oxide Delivery

DC Field Value Language
dc.contributor.authorHyung Woo Choi-
dc.contributor.authorJihoon Kim-
dc.contributor.authorKim J.-
dc.contributor.authorYonghwi Kim-
dc.contributor.authorSong H.B.-
dc.contributor.authorKim J.H.-
dc.contributor.authorKimoon Kim-
dc.contributor.authorWon Jong Kim-
dc.date.available2016-07-19T07:40:09Z-
dc.date.created2016-06-20-
dc.date.issued2016-04-
dc.identifier.issn1936-0851-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/2679-
dc.description.abstractWe report herein the design of a light-responsive gatekeeper for smart nitric oxide (NO) delivery. The gatekeeper is composed of a pH-jump reagent as an intermediary of stimulus and a calcium phosphate (CaP) coating as a shielding layer for NO release. The light irradiation and subsequent acid generation are used as triggers for uncapping the gatekeeper and releasing NO. The acids generated from a light-activated pH-jump agent loaded in the mesoporous nanoparticles accelerated the degradation of the CaP-coating layers on the nanoparticles, facilitating the light-responsive NO release from diazeniumdiolate by exposing a NO donor to physiological conditions. Using the combination of the pH-jump reagent and CaP coating, we successfully developed a light-responsive gatekeeper system for spatiotemporal-controlled NO delivery. © 2016 American Chemical Society-
dc.description.uri1-
dc.language영어-
dc.publisherAMER CHEMICAL SOC-
dc.subjectcalcium phosphate-
dc.subjectcorneal wound healing-
dc.subjectgatekeeper-
dc.subjectnitric oxide delivery-
dc.subjectpH-jump reagent-
dc.titleLight-Induced Acid Generation on a Gatekeeper for Smart Nitric Oxide Delivery-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000375245000036-
dc.identifier.scopusid2-s2.0-84968735648-
dc.identifier.rimsid55857ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorHyung Woo Choi-
dc.contributor.affiliatedAuthorJihoon Kim-
dc.contributor.affiliatedAuthorYonghwi Kim-
dc.contributor.affiliatedAuthorKimoon Kim-
dc.contributor.affiliatedAuthorWon Jong Kim-
dc.identifier.doi10.1021/acsnano.5b07483-
dc.identifier.bibliographicCitationACS NANO, v.10, no.4, pp.4199 - 4208-
dc.citation.titleACS NANO-
dc.citation.volume10-
dc.citation.number4-
dc.citation.startPage4199-
dc.citation.endPage4208-
dc.date.scptcdate2018-10-01-
dc.description.wostc26-
dc.description.scptc25-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordAuthorcalcium phosphate-
dc.subject.keywordAuthorcorneal wound healing-
dc.subject.keywordAuthorgatekeeper-
dc.subject.keywordAuthornitric oxide delivery-
dc.subject.keywordAuthorpH-jump reagent-
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
복잡계_자기조립_연구단_논문.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse