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나노 구조 물리 연구단
나노구조물리 연구단
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ZnO nanowire arrays on 3D-hierachical graphene foam: Biomarker detection of Parkinson's disease Highly Cited Paper

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Title
ZnO nanowire arrays on 3D-hierachical graphene foam: Biomarker detection of Parkinson's disease
Author(s)
Hongyan Yue; Shuo Huang; Jian Chang; Chaejeong Heo; Fei Yao; Subash Adhikari; Fethullah Gunes; Li Chun Liu; Tae Hoon Lee; Eung Seok Oh; Bing Li; Jian Jiao Zhang; Ta Quang Huy; Nguyen Van Luan; Young Hee Lee
Publication Date
2014-02
Journal
ACS NANO, v.8, no.2, pp.1639 - 1646
Publisher
AMER CHEMICAL SOC
Abstract
We report that vertically aligned ZnO nanowire arrays (ZnO NWAs) were fabricated on 3D graphene foam (GF) and used to selectively detect uric acid (UA), dopamine (DA), and ascorbic acid (AA) by a differential pulse voltammetry method. The optimized ZnO NWA/GF electrode provided a high surface area and high selectivity with a detection limit of 1 nM for UA and DA. The high selectivity in the oxidation potential was explained by the gap difference between the lowest unoccupied and highest occupied molecular orbitals of a biomolecule for a set of given electrodes. This method was further used to detect UA levels in the serum of patients with Parkinson's disease (PD). The UA level was 25% lower in PD patients than in healthy individuals. This finding strongly implies that UA can be used as a biomarker for PD.
URI
https://pr.ibs.re.kr/handle/8788114/1124
ISSN
1936-0851
Appears in Collections:
Center for Integrated Nanostructure Physics(나노구조물리 연구단) > Journal Papers (저널논문)
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
Files in This Item:
007_(ACS Nano)_ 2014.Jan_허채정.pdfDownload

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