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- 복잡계자기조립연구단
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IBS Publications RepositoryCenter for Self-assembly and Complexity(복잡계 자기조립 연구단)1. Journal Papers (저널논문)
Target identification of mouse stem cell probe CDy1 as ALDH2 and Abcb1b through live-cell affinity-matrix and ABC CRISPRa library
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- Title
- Target identification of mouse stem cell probe CDy1 as ALDH2 and Abcb1b through live-cell affinity-matrix and ABC CRISPRa library
- Author(s)
- Naoki Miyamoto; Go, Young-Hyun; Larissa Miasiro Ciaramicoli; Haw-Young Kwon; Kim, Heon Seok; Bi, Xuezhi; Yu, Young Hyun; Kim, Beomsue; Ha, Hyung-Ho; Kang, Nam-Young; Yun, Seong-Wook; Jin-Soo Kim; Cha, Hyuk-Jin; Young-Tae Chang
- Publication Date
- 2021-12
- Journal
- RSC Chemical Biology, v.2, no.6, pp.1590 - 1593
- Publisher
- Royal Society of Chemistry
- Abstract
- © The Royal Society of Chemistry.CDy1 is a powerful tool to distingusih embryonic stem cells for reprogramming studies and regeneration medicine. However, the stem cell selectivity mechanism of CDy1 has not been fully understood. Here, we report ALDH2 and ABCB1 as the molecular targets of CDy1, elucidated by live-cell affinity-matrix and ABC transporter CRISPRa library screening. The two unique orthogonal mechanisms provide the potential of multi-demensional cellular distinction of specific cell types.
- ISSN
- 2633-0679
- Appears in Collections:
- Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
Center for Genome Engineering(유전체 교정 연구단) > 1. Journal Papers (저널논문)
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