BROWSE

Related Scientist

Naoki, Miyamoto's photo.

Naoki, Miyamoto
복잡계 자기조립 연구단
more info

ITEM VIEW & DOWNLOAD

Target identification of mouse stem cell probe CDy1 as ALDH2 and Abcb1b through live-cell affinity-matrix and ABC CRISPRa library

Cited 0 time in webofscience Cited 0 time in scopus
13 Viewed 0 Downloaded
Title
Target identification of mouse stem cell probe CDy1 as ALDH2 and Abcb1b through live-cell affinity-matrix and ABC CRISPRa library
Author(s)
Naoki Miyamoto; Go, Young-Hyun; Larissa Miasiro Ciaramicoli; Haw-Young Kwon; Kim, Heon Seok; Bi, Xuezhi; Yu, Young Hyun; Kim, Beomsue; Ha, Hyung-Ho; Kang, Nam-Young; Yun, Seong-Wook; Jin-Soo Kim; Cha, Hyuk-Jin; Young-Tae Chang
Publication Date
2021-12
Journal
RSC Chemical Biology, v.2, no.6, pp.1590 - 1593
Publisher
Royal Society of Chemistry
Abstract
© The Royal Society of Chemistry.CDy1 is a powerful tool to distingusih embryonic stem cells for reprogramming studies and regeneration medicine. However, the stem cell selectivity mechanism of CDy1 has not been fully understood. Here, we report ALDH2 and ABCB1 as the molecular targets of CDy1, elucidated by live-cell affinity-matrix and ABC transporter CRISPRa library screening. The two unique orthogonal mechanisms provide the potential of multi-demensional cellular distinction of specific cell types.
URI
https://pr.ibs.re.kr/handle/8788114/10992
DOI
10.1039/d1cb00147g
ISSN
2633-0679
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
Center for Genome Engineering(유전체 교정 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse