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Localized Delivery of Theranostic Nanoparticles and High-Energy Photons using Microneedles-on-Bioelectronics

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Title
Localized Delivery of Theranostic Nanoparticles and High-Energy Photons using Microneedles-on-Bioelectronics
Author(s)
Youngsik Lee; Taegyu Kang; Hye Rim Cho; Lee, Gil Ju; Ok Kyu Park; Sangyeon Kim; Bowon Lee; Kim, Hyun Myung; Gi Doo Cha; Yoonsoo Shin; Wanghee Lee; Minjeong Kim; Hyunjoong Kim; Song, Young Min; Seung Hong Choi; Taeghwan Hyeon; Dae-Hyeong Kim
Publication Date
2021-06
Journal
Advanced Materials, v.33, no.24
Publisher
John Wiley and Sons Inc
Abstract
© 2021 Wiley-VCH GmbHThe low delivery efficiency of light-responsive theranostic nanoparticles (NPs) to target tumor sites, particularly to brain tumors due to the blood–brain barrier, has been a critical issue in NP-based cancer treatments. Furthermore, high-energy photons that can effectively activate theranostic NPs are hardly delivered to the target region due to the strong scattering of such photons while penetrating surrounding tissues. Here, a localized delivery method of theranostic NPs and high-energy photons to the target tumor using microneedles-on-bioelectronics is presented. Two types of microneedles and flexible bioelectronics are integrated and mounted on the edge of surgical forceps. Bioresorbable microneedles containing theranostic NPs deliver the NPs into target tumors (e.g., glioblastoma, pituitary adenoma). Magnetic resonance imaging can locate the NPs. Then, light-guiding/spreading microneedles deliver high-energy photons from bioelectronics to the NPs. The high-energy photons activate the NPs to treat tumor tissues by photodynamic therapy and chemotherapy. The controlled thermal actuation by the bioelectronics accelerates the diffusion of chemo-drugs. The proposed method is demonstrated with mouse tumor models in vivo.
URI
https://pr.ibs.re.kr/handle/8788114/10774
DOI
10.1002/adma.202100425
ISSN
0935-9648
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
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