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Localized Delivery of Theranostic Nanoparticles and High-Energy Photons using Microneedles-on-Bioelectronics

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dc.contributor.authorYoungsik Lee-
dc.contributor.authorTaegyu Kang-
dc.contributor.authorHye Rim Cho-
dc.contributor.authorLee, Gil Ju-
dc.contributor.authorOk Kyu Park-
dc.contributor.authorSangyeon Kim-
dc.contributor.authorBowon Lee-
dc.contributor.authorKim, Hyun Myung-
dc.contributor.authorGi Doo Cha-
dc.contributor.authorYoonsoo Shin-
dc.contributor.authorWanghee Lee-
dc.contributor.authorMinjeong Kim-
dc.contributor.authorHyunjoong Kim-
dc.contributor.authorSong, Young Min-
dc.contributor.authorSeung Hong Choi-
dc.contributor.authorTaeghwan Hyeon-
dc.contributor.authorDae-Hyeong Kim-
dc.date.accessioned2021-12-07T07:50:21Z-
dc.date.available2021-12-07T07:50:21Z-
dc.date.created2021-05-27-
dc.date.issued2021-06-
dc.identifier.issn0935-9648-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/10774-
dc.description.abstract© 2021 Wiley-VCH GmbHThe low delivery efficiency of light-responsive theranostic nanoparticles (NPs) to target tumor sites, particularly to brain tumors due to the blood–brain barrier, has been a critical issue in NP-based cancer treatments. Furthermore, high-energy photons that can effectively activate theranostic NPs are hardly delivered to the target region due to the strong scattering of such photons while penetrating surrounding tissues. Here, a localized delivery method of theranostic NPs and high-energy photons to the target tumor using microneedles-on-bioelectronics is presented. Two types of microneedles and flexible bioelectronics are integrated and mounted on the edge of surgical forceps. Bioresorbable microneedles containing theranostic NPs deliver the NPs into target tumors (e.g., glioblastoma, pituitary adenoma). Magnetic resonance imaging can locate the NPs. Then, light-guiding/spreading microneedles deliver high-energy photons from bioelectronics to the NPs. The high-energy photons activate the NPs to treat tumor tissues by photodynamic therapy and chemotherapy. The controlled thermal actuation by the bioelectronics accelerates the diffusion of chemo-drugs. The proposed method is demonstrated with mouse tumor models in vivo.-
dc.language영어-
dc.publisherJohn Wiley and Sons Inc-
dc.titleLocalized Delivery of Theranostic Nanoparticles and High-Energy Photons using Microneedles-on-Bioelectronics-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000647481300001-
dc.identifier.scopusid2-s2.0-85105136111-
dc.identifier.rimsid75687-
dc.contributor.affiliatedAuthorYoungsik Lee-
dc.contributor.affiliatedAuthorTaegyu Kang-
dc.contributor.affiliatedAuthorHye Rim Cho-
dc.contributor.affiliatedAuthorOk Kyu Park-
dc.contributor.affiliatedAuthorSangyeon Kim-
dc.contributor.affiliatedAuthorBowon Lee-
dc.contributor.affiliatedAuthorGi Doo Cha-
dc.contributor.affiliatedAuthorYoonsoo Shin-
dc.contributor.affiliatedAuthorWanghee Lee-
dc.contributor.affiliatedAuthorMinjeong Kim-
dc.contributor.affiliatedAuthorHyunjoong Kim-
dc.contributor.affiliatedAuthorSeung Hong Choi-
dc.contributor.affiliatedAuthorTaeghwan Hyeon-
dc.contributor.affiliatedAuthorDae-Hyeong Kim-
dc.identifier.doi10.1002/adma.202100425-
dc.identifier.bibliographicCitationAdvanced Materials, v.33, no.24-
dc.relation.isPartOfAdvanced Materials-
dc.citation.titleAdvanced Materials-
dc.citation.volume33-
dc.citation.number24-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalResearchAreaMaterials Science-
dc.relation.journalResearchAreaPhysics-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryChemistry, Physical-
dc.relation.journalWebOfScienceCategoryNanoscience & Nanotechnology-
dc.relation.journalWebOfScienceCategoryMaterials Science, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryPhysics, Applied-
dc.relation.journalWebOfScienceCategoryPhysics, Condensed Matter-
dc.subject.keywordAuthorbrain tumors-
dc.subject.keywordAuthorcancer treatment-
dc.subject.keywordAuthorhigh-energy photons-
dc.subject.keywordAuthorlight-responsive nanoparticles-
dc.subject.keywordAuthormicroneedles-
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
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