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Visualization of lipophagy using a supramolecular FRET pair

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Title
Visualization of lipophagy using a supramolecular FRET pair
Author(s)
Ara Lee; Meng Li; Young Ho Ko; Park, Sanghwang; Seo, Jongcheol; Kyeng Min Park; Kimoon Kim
Publication Date
2021-11-16
Journal
CHEMICAL COMMUNICATIONS, v.57, no.91, pp.12179 - 12182
Publisher
ROYAL SOC CHEMISTRY
Abstract
A rationally designed supramolecular FRET pair consisting of cyanine3-cucurbit[7]uril (Cy3-CB[7]) and boron-dipyrromethene 630/650-adamantylammonium (BDP-AdA) can be used to visualize organelle-specific autophagy events. The intracellular accumulations of Cy3-CB[7] in lysosomes and BDP-AdA in lipid droplets (LDs) and the formation of an intracellular host-guest complex between Cy3-CB[7] and BDP-AdA resulting in FRET signals allow us to visualize the fusion of LDs with lysosomes, namely, lipophagy. This study demonstrates the potential of supramolecular imaging based on bio-orthogonal host-guest interactions in the investigation of selective autophagy events.
URI
https://pr.ibs.re.kr/handle/8788114/10740
DOI
10.1039/d1cc04779e
ISSN
1359-7345
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
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