BROWSE

Related Scientist

CSC's photo.

CSC
복잡계 자기조립 연구단
more info

ITEM VIEW & DOWNLOAD

A Near-Infrared Organic Fluorescent Probe for Broad Applications for Blood Vessels Imaging by High-Throughput Screening via 3D-Blood Vessel Models

Cited 0 time in webofscience Cited 0 time in scopus
6 Viewed 0 Downloaded
Title
A Near-Infrared Organic Fluorescent Probe for Broad Applications for Blood Vessels Imaging by High-Throughput Screening via 3D-Blood Vessel Models
Author(s)
Abdul Sisak, Muhammad Asri; Louis, Fiona; Aoki, Ichio; Sun Hyeok Lee; Young-Tae Chang; Matsusaki, Michiya
Publication Date
2021-08
Journal
SMALL METHODS, v.5, no.8
Publisher
John Wiley and Sons Inc
Abstract
© 2021 Wiley-VCH GmbHBlood vessels are present in all of the organs, reflecting their importance for oxygen and nutrient delivery to the cells. Until now, no organic fluorophore has been reported for the live imaging of endothelium although the layer is the key to blood vessel functions. Here, the discovery of a blood vessel organic probe at near-infrared (NIR) wavelength range (BV-NIR) through an engineered blood capillary-based screening system, which is a more physiological model than a conventional cell culture condition, is reported. This selected Cy5 based probe shows the highest specific adsorption property out of 240 candidates on the endothelium and is equivalent to an anti-CD31 antibody in terms of intensity. The BV-NIR probe indicating strong and stable in vitro, ex vivo, and in vivo imaging of the endothelium even after histological immunostaining processes shows potential as a convenient tool for live imaging as well as for covisualization with a specific antibody.
URI
https://pr.ibs.re.kr/handle/8788114/10691
DOI
10.1002/smtd.202100338
ISSN
2366-9608
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse