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복잡계 자기조립 연구단
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A Near-Infrared Organic Fluorescent Probe for Broad Applications for Blood Vessels Imaging by High-Throughput Screening via 3D-Blood Vessel Models

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dc.contributor.authorAbdul Sisak, Muhammad Asri-
dc.contributor.authorLouis, Fiona-
dc.contributor.authorAoki, Ichio-
dc.contributor.authorSun Hyeok Lee-
dc.contributor.authorYoung-Tae Chang-
dc.contributor.authorMatsusaki, Michiya-
dc.date.accessioned2021-11-19T07:50:01Z-
dc.date.available2021-11-19T07:50:01Z-
dc.date.created2021-07-07-
dc.date.issued2021-08-
dc.identifier.issn2366-9608-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/10691-
dc.description.abstract© 2021 Wiley-VCH GmbHBlood vessels are present in all of the organs, reflecting their importance for oxygen and nutrient delivery to the cells. Until now, no organic fluorophore has been reported for the live imaging of endothelium although the layer is the key to blood vessel functions. Here, the discovery of a blood vessel organic probe at near-infrared (NIR) wavelength range (BV-NIR) through an engineered blood capillary-based screening system, which is a more physiological model than a conventional cell culture condition, is reported. This selected Cy5 based probe shows the highest specific adsorption property out of 240 candidates on the endothelium and is equivalent to an anti-CD31 antibody in terms of intensity. The BV-NIR probe indicating strong and stable in vitro, ex vivo, and in vivo imaging of the endothelium even after histological immunostaining processes shows potential as a convenient tool for live imaging as well as for covisualization with a specific antibody.-
dc.language영어-
dc.publisherJohn Wiley and Sons Inc-
dc.titleA Near-Infrared Organic Fluorescent Probe for Broad Applications for Blood Vessels Imaging by High-Throughput Screening via 3D-Blood Vessel Models-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000661961800001-
dc.identifier.scopusid2-s2.0-85107911330-
dc.identifier.rimsid75940-
dc.contributor.affiliatedAuthorSun Hyeok Lee-
dc.contributor.affiliatedAuthorYoung-Tae Chang-
dc.identifier.doi10.1002/smtd.202100338-
dc.identifier.bibliographicCitationSMALL METHODS, v.5, no.8-
dc.relation.isPartOfSMALL METHODS-
dc.citation.titleSMALL METHODS-
dc.citation.volume5-
dc.citation.number8-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalResearchAreaMaterials Science-
dc.relation.journalWebOfScienceCategoryChemistry, Physical-
dc.relation.journalWebOfScienceCategoryNanoscience & Nanotechnology-
dc.relation.journalWebOfScienceCategoryMaterials Science, Multidisciplinary-
dc.subject.keywordPlusENDOTHELIAL-CELLS-
dc.subject.keywordPlusQUANTUM DOTS-
dc.subject.keywordPlusNANOPARTICLES-
dc.subject.keywordPlusCOLLAGEN-
dc.subject.keywordPlusTISSUE-
dc.subject.keywordPlusFLUOROPHORES-
dc.subject.keywordPlusDISCOVERY-
dc.subject.keywordAuthor3D-blood capillary models-
dc.subject.keywordAuthorantibodies-
dc.subject.keywordAuthorfibrin gels-
dc.subject.keywordAuthorfluorescent probes-
dc.subject.keywordAuthorin vivo imaging-
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
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