BROWSE

Related Scientist

Kwon, Haw Young's photo.

Kwon, Haw Young
복잡계 자기조립 연구단
more info

ITEM VIEW & DOWNLOAD

Lipid-Oriented Live-Cell Distinction of B and T Lymphocytes

Cited 0 time in webofscience Cited 0 time in scopus
4 Viewed 0 Downloaded
Title
Lipid-Oriented Live-Cell Distinction of B and T Lymphocytes
Author(s)
Haw-Young Kwon; Kumar Das, Raj; Jung, Gun Tae; 복잡계 자기조립 연구단; Lee, Sun Hyeok; Berry, Stuart N.; Tan, Justin Kok Soon; Park, Solip; Yang, Jae-Seong; Park, Soohyun; Kangkyun Baek; Kyeng Min Park; Lee, Jae Won; Choi, Yun-Kyu; Kim, Ki Hean; Kim, Sangho; Kim, Kwang Pyo; Kang, Nam-Young; Kimoon Kim; Young-Tae Chang
Publication Date
2021-04
Journal
Journal of the American Chemical Society, v.143, no.15, pp.5836 - 5844
Publisher
American Chemical Society
Abstract
© The identification of each cell type is essential for understanding multicellular communities. Antibodies set as biomarkers have been the main toolbox for cell-type recognition, and chemical probes are emerging surrogates. Herein we report the first small-molecule probe, CDgB, to discriminate B lymphocytes from T lymphocytes, which was previously impossible without the help of antibodies. Through the study of the origin of cell specificity, we discovered an unexpected novel mechanism of membrane-oriented live-cell distinction. B cells maintain higher flexibility in their cell membrane than T cells and accumulate the lipid-like probe CDgB more preferably. Because B and T cells share common ancestors, we tracked the cell membrane changes of the progenitor cells and disclosed the dynamic reorganization of the membrane properties over the lymphocyte differentiation progress. This study casts an orthogonal strategy for the small-molecule cell identifier and enriches the toolbox for live-cell distinction from complex cell communities.
URI
https://pr.ibs.re.kr/handle/8788114/9993
DOI
10.1021/jacs.1c00944
ISSN
0002-7863
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse