BROWSE

Related Scientist

Kwon, Haw Young's photo.

Kwon, Haw Young
복잡계 자기조립 연구단
more info

ITEM VIEW & DOWNLOAD

Lipid-Oriented Live-Cell Distinction of B and T Lymphocytes

DC Field Value Language
dc.contributor.authorHaw-Young Kwon-
dc.contributor.authorKumar Das, Raj-
dc.contributor.authorJung, Gun Tae-
dc.contributor.author복잡계 자기조립 연구단-
dc.contributor.authorLee, Sun Hyeok-
dc.contributor.authorBerry, Stuart N.-
dc.contributor.authorTan, Justin Kok Soon-
dc.contributor.authorPark, Solip-
dc.contributor.authorYang, Jae-Seong-
dc.contributor.authorPark, Soohyun-
dc.contributor.authorKangkyun Baek-
dc.contributor.authorKyeng Min Park-
dc.contributor.authorLee, Jae Won-
dc.contributor.authorChoi, Yun-Kyu-
dc.contributor.authorKim, Ki Hean-
dc.contributor.authorKim, Sangho-
dc.contributor.authorKim, Kwang Pyo-
dc.contributor.authorKang, Nam-Young-
dc.contributor.authorKimoon Kim-
dc.contributor.authorYoung-Tae Chang-
dc.date.accessioned2021-07-22T07:30:05Z-
dc.date.accessioned2021-07-22T07:30:05Z-
dc.date.available2021-07-22T07:30:05Z-
dc.date.available2021-07-22T07:30:05Z-
dc.date.created2021-05-27-
dc.date.issued2021-04-
dc.identifier.issn0002-7863-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/9993-
dc.description.abstract© The identification of each cell type is essential for understanding multicellular communities. Antibodies set as biomarkers have been the main toolbox for cell-type recognition, and chemical probes are emerging surrogates. Herein we report the first small-molecule probe, CDgB, to discriminate B lymphocytes from T lymphocytes, which was previously impossible without the help of antibodies. Through the study of the origin of cell specificity, we discovered an unexpected novel mechanism of membrane-oriented live-cell distinction. B cells maintain higher flexibility in their cell membrane than T cells and accumulate the lipid-like probe CDgB more preferably. Because B and T cells share common ancestors, we tracked the cell membrane changes of the progenitor cells and disclosed the dynamic reorganization of the membrane properties over the lymphocyte differentiation progress. This study casts an orthogonal strategy for the small-molecule cell identifier and enriches the toolbox for live-cell distinction from complex cell communities.-
dc.description.uri1-
dc.language영어-
dc.publisherAmerican Chemical Society-
dc.titleLipid-Oriented Live-Cell Distinction of B and T Lymphocytes-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000643591600034-
dc.identifier.scopusid2-s2.0-85105058870-
dc.identifier.rimsid75691-
dc.contributor.affiliatedAuthorHaw-Young Kwon-
dc.contributor.affiliatedAuthor복잡계 자기조립 연구단-
dc.contributor.affiliatedAuthorKangkyun Baek-
dc.contributor.affiliatedAuthorKyeng Min Park-
dc.contributor.affiliatedAuthorKimoon Kim-
dc.contributor.affiliatedAuthorYoung-Tae Chang-
dc.identifier.doi10.1021/jacs.1c00944-
dc.identifier.bibliographicCitationJournal of the American Chemical Society, v.143, no.15, pp.5836 - 5844-
dc.citation.titleJournal of the American Chemical Society-
dc.citation.volume143-
dc.citation.number15-
dc.citation.startPage5836-
dc.citation.endPage5844-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.subject.keywordPlusPROBE-
dc.subject.keywordPlusIDENTIFICATION-
dc.subject.keywordPlusBINDING-
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse