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Non-contact long-range magnetic stimulation of mechanosensitive ion channels in freely moving animals

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Title
Non-contact long-range magnetic stimulation of mechanosensitive ion channels in freely moving animals
Author(s)
Jung-uk Lee; Wookjin Shin; Yongjun Lim; Jungsil Kim; Woon Ryoung Kim; Heehun Kim; Jae-Hyun Lee; Jinwoo Cheon
Publication Date
2021-07
Journal
NATURE MATERIALS, v.20, no.7, pp.1029 - 1036
Publisher
NATURE RESEARCH
Abstract
Among physical stimulation modalities, magnetism has clear advantages, such as deep penetration and untethered interventions in biological subjects. However, some of the working principles and effectiveness of existing magnetic neurostimulation approaches have been challenged, leaving questions to be answered. Here we introduce m-Torquer, a magnetic toolkit that mimics magnetoreception in nature. It comprises a nanoscale magnetic torque actuator and a circular magnet array, which deliver piconewton-scale forces to cells over a working range of similar to 70 cm. With m-Torquer, stimulation of neurons expressing bona fide mechanosensitive ion channel Piezo1 enables consistent and reproducible neuromodulation in freely moving mice. With its long working distance and cellular targeting capability, m-Torquer provides versatility in its use, which can range from single cells to in vivo systems, with the potential application in large animals such as primates.
URI
https://pr.ibs.re.kr/handle/8788114/9970
DOI
10.1038/s41563-020-00896-y
ISSN
1476-1122
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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