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나노의학 연구단
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Non-contact long-range magnetic stimulation of mechanosensitive ion channels in freely moving animals

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dc.contributor.authorJung-uk Lee-
dc.contributor.authorWookjin Shin-
dc.contributor.authorYongjun Lim-
dc.contributor.authorJungsil Kim-
dc.contributor.authorWoon Ryoung Kim-
dc.contributor.authorHeehun Kim-
dc.contributor.authorJae-Hyun Lee-
dc.contributor.authorJinwoo Cheon-
dc.date.accessioned2021-07-19T02:30:11Z-
dc.date.accessioned2021-07-19T02:30:11Z-
dc.date.available2021-07-19T02:30:11Z-
dc.date.available2021-07-19T02:30:11Z-
dc.date.created2021-02-23-
dc.date.issued2021-07-
dc.identifier.issn1476-1122-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/9970-
dc.description.abstractAmong physical stimulation modalities, magnetism has clear advantages, such as deep penetration and untethered interventions in biological subjects. However, some of the working principles and effectiveness of existing magnetic neurostimulation approaches have been challenged, leaving questions to be answered. Here we introduce m-Torquer, a magnetic toolkit that mimics magnetoreception in nature. It comprises a nanoscale magnetic torque actuator and a circular magnet array, which deliver piconewton-scale forces to cells over a working range of similar to 70 cm. With m-Torquer, stimulation of neurons expressing bona fide mechanosensitive ion channel Piezo1 enables consistent and reproducible neuromodulation in freely moving mice. With its long working distance and cellular targeting capability, m-Torquer provides versatility in its use, which can range from single cells to in vivo systems, with the potential application in large animals such as primates.-
dc.description.uri1-
dc.language영어-
dc.publisherNATURE RESEARCH-
dc.titleNon-contact long-range magnetic stimulation of mechanosensitive ion channels in freely moving animals-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000612595500002-
dc.identifier.scopusid2-s2.0-85099970026-
dc.identifier.rimsid74559-
dc.contributor.affiliatedAuthorJung-uk Lee-
dc.contributor.affiliatedAuthorWookjin Shin-
dc.contributor.affiliatedAuthorYongjun Lim-
dc.contributor.affiliatedAuthorJungsil Kim-
dc.contributor.affiliatedAuthorWoon Ryoung Kim-
dc.contributor.affiliatedAuthorHeehun Kim-
dc.contributor.affiliatedAuthorJae-Hyun Lee-
dc.contributor.affiliatedAuthorJinwoo Cheon-
dc.identifier.doi10.1038/s41563-020-00896-y-
dc.identifier.bibliographicCitationNATURE MATERIALS, v.20, no.7, pp.1029 - 1036-
dc.citation.titleNATURE MATERIALS-
dc.citation.volume20-
dc.citation.number7-
dc.citation.startPage1029-
dc.citation.endPage1036-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalWebOfScienceCategoryChemistry, Physical-
dc.relation.journalWebOfScienceCategoryMaterials Science, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryPhysics, Applied-
dc.relation.journalWebOfScienceCategoryPhysics, Condensed Matter-
dc.subject.keywordPlusMECHANICAL FORCES-
dc.subject.keywordPlusCANCER-
dc.subject.keywordPlusMECHANOTRANSDUCTION-
dc.subject.keywordPlusPIEZO2-
dc.subject.keywordPlusDNA-
dc.subject.keywordAuthorMECHANICAL FORCES-
dc.subject.keywordAuthorCANCER-
dc.subject.keywordAuthorMECHANOTRANSDUCTION-
dc.subject.keywordAuthorPIEZO2-
dc.subject.keywordAuthorDNA-
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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