BROWSE

Related Scientist

CCS's photo.

CCS
인지 및 사회성 연구단
more info

ITEM VIEW & DOWNLOAD

The pathological role of astrocytic MAOB in parkinsonism revealed by genetic ablation and over-expression of MAOB

Cited 0 time in webofscience Cited 0 time in scopus
45 Viewed 0 Downloaded
Title
The pathological role of astrocytic MAOB in parkinsonism revealed by genetic ablation and over-expression of MAOB
Author(s)
Heeyoung An; Heo, Jun Young; C. Justin Lee; Nam, Min-Ho
Publication Date
2021-04
Journal
Experimental Neurobiology, v.30, no.2, pp.113 - 119
Publisher
Korean Society for Neurodegenerative Disease
Abstract
©opyright © Experimental Neurobiology 2021. www.enjournal.org The cause of Parkinson’s disease has been traditionally believed to be the dopaminergic neuronal death in the substantia nigra pars compacta (SNpc). This traditional view has been recently challenged by the proposal that reactive astrocytes serve as key players in the pathology of Parkinson’s disease through excessive GABA release. This aberrant astrocytic GABA is synthesized by the enzymatic action of monoamine oxidase B (MAOB), whose pharmacological inhibition and gene-silencing are reported to significantly alleviate parkinsonian motor symptoms in animal models of Parkinson’s disease. However, whether genetic ablation and over-expression of MAOB can bidirectionally regulate parkinsonian motor symptoms has not been tested. Here we demonstrate that genetic ablation of MAOB blocks the MPTP-induced augmentation of astrocytic GABA-mediated tonic inhibition of neighboring dopaminergic neurons as well as parkinsonian motor symptoms, indicating the necessity of MAOB for parkinsonian motor symptoms. Furthermore, we demonstrate that GFAP-MAOB transgenic mice, in which MAOB is over-expressed under the GFAP promoter for astrocyte-specific over-expression, display exacerbated MPTP-induced tonic inhibition and parkinsonian motor symptoms compared to wild-type mice, indicating the importance of astrocytic MAOB for parkinsonian motor symptoms. Our study provides genetic pieces of evidence for the causal link between the pathological role of astrocytic MAOB-dependent tonic GABA synthesis and parkinsonian motor symptoms.
URI
https://pr.ibs.re.kr/handle/8788114/9877
DOI
10.5607/en21007
ISSN
1226-2560
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse