BROWSE

Related Scientist

CCS's photo.

CCS
인지 및 사회성 연구단
more info

ITEM VIEW & DOWNLOAD

The pathological role of astrocytic MAOB in parkinsonism revealed by genetic ablation and over-expression of MAOB

DC Field Value Language
dc.contributor.authorHeeyoung An-
dc.contributor.authorHeo, Jun Young-
dc.contributor.authorC. Justin Lee-
dc.contributor.authorNam, Min-Ho-
dc.date.accessioned2021-07-08T04:30:08Z-
dc.date.accessioned2021-07-08T04:30:08Z-
dc.date.available2021-07-08T04:30:08Z-
dc.date.available2021-07-08T04:30:08Z-
dc.date.created2021-07-07-
dc.date.issued2021-04-
dc.identifier.issn1226-2560-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/9877-
dc.description.abstract©opyright © Experimental Neurobiology 2021. www.enjournal.org The cause of Parkinson’s disease has been traditionally believed to be the dopaminergic neuronal death in the substantia nigra pars compacta (SNpc). This traditional view has been recently challenged by the proposal that reactive astrocytes serve as key players in the pathology of Parkinson’s disease through excessive GABA release. This aberrant astrocytic GABA is synthesized by the enzymatic action of monoamine oxidase B (MAOB), whose pharmacological inhibition and gene-silencing are reported to significantly alleviate parkinsonian motor symptoms in animal models of Parkinson’s disease. However, whether genetic ablation and over-expression of MAOB can bidirectionally regulate parkinsonian motor symptoms has not been tested. Here we demonstrate that genetic ablation of MAOB blocks the MPTP-induced augmentation of astrocytic GABA-mediated tonic inhibition of neighboring dopaminergic neurons as well as parkinsonian motor symptoms, indicating the necessity of MAOB for parkinsonian motor symptoms. Furthermore, we demonstrate that GFAP-MAOB transgenic mice, in which MAOB is over-expressed under the GFAP promoter for astrocyte-specific over-expression, display exacerbated MPTP-induced tonic inhibition and parkinsonian motor symptoms compared to wild-type mice, indicating the importance of astrocytic MAOB for parkinsonian motor symptoms. Our study provides genetic pieces of evidence for the causal link between the pathological role of astrocytic MAOB-dependent tonic GABA synthesis and parkinsonian motor symptoms.-
dc.description.uri1-
dc.language영어-
dc.publisherKorean Society for Neurodegenerative Disease-
dc.titleThe pathological role of astrocytic MAOB in parkinsonism revealed by genetic ablation and over-expression of MAOB-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000654000200002-
dc.identifier.scopusid2-s2.0-85106737109-
dc.identifier.rimsid76026-
dc.contributor.affiliatedAuthorHeeyoung An-
dc.contributor.affiliatedAuthorC. Justin Lee-
dc.identifier.doi10.5607/en21007-
dc.identifier.bibliographicCitationExperimental Neurobiology, v.30, no.2, pp.113 - 119-
dc.citation.titleExperimental Neurobiology-
dc.citation.volume30-
dc.citation.number2-
dc.citation.startPage113-
dc.citation.endPage119-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalWebOfScienceCategoryMedicine, Research & Experimental-
dc.relation.journalWebOfScienceCategoryNeurosciences-
dc.subject.keywordPlusGABA-
dc.subject.keywordPlusINFLAMMATION-
dc.subject.keywordPlusMODEL-
dc.subject.keywordAuthorAstrocyte-
dc.subject.keywordAuthorMAOB-
dc.subject.keywordAuthorMPTP-
dc.subject.keywordAuthorParkinson’s disease-
dc.subject.keywordAuthorTonic GABA-
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse